{"id":69808,"date":"2004-03-09T00:00:00","date_gmt":"2004-03-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-expresion-genica-mediada-por-poli-adp-ribosa-polimerasa-1-en-la-celula-endotelial\/"},"modified":"2004-03-09T00:00:00","modified_gmt":"2004-03-09T00:00:00","slug":"regulacion-de-la-expresion-genica-mediada-por-poli-adp-ribosa-polimerasa-1-en-la-celula-endotelial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/regulacion-de-la-expresion-genica-mediada-por-poli-adp-ribosa-polimerasa-1-en-la-celula-endotelial\/","title":{"rendered":"Regulacion de la expresion genica mediada por poli adp ribosa polimerasa 1 en la celula endotelial"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Carrillo Redondo <\/strong><\/h2>\n<p>La alteraci\u00f3n funcional de la c\u00e9lula endotelial es un fen\u00f3meno importante que ocurre de forma precoz en multitud de procesos patol\u00f3gicos como es el da\u00f1o por isquemia y reperfusi\u00f3n, teniendo un papel crucial en condiciones inflamatorias descontroladas como son la sepsis o el s\u00edndrome de respuesta inflamatoria sist\u00e9mica. Los mediadores inflamatorios que se liberan tras un est\u00edmulo, inician una serie de v\u00edas de se\u00f1alizaci\u00f3n al n\u00facleo en la c\u00e9lula endotelial, mediados por nf-kb y otros factores de transcripci\u00f3n que alteran el programa de expresi\u00f3n g\u00e9nica de la c\u00e9lula. El resultado final es una desregulaci\u00f3n de la funci\u00f3n endotelial, dando lugar a un incremento de la adhesi\u00f3n y permeabilidad vascular, trombosis, etc, provocando alteraciones fisiopatol\u00f3gicas que pueden culminar en disfunci\u00f3n multiorg\u00e1nica y a menudo la muerte. El factor de necrosis tumoral-alpha (tnf-alpha) es uno de los mediadores m\u00e1s importantes de los procesos inflamatorios, y se han identificado un gran n\u00famero de genes sensibles a esta citoquina. La expresi\u00f3n de genes dependientes de tnf-alpha est\u00e1 mediada principalmente por el factor de transcripci\u00f3n nf-kb. Bajo condiciones basales, nf-kb se encuentra secuestrado en el citoplasma de la c\u00e9lula, unido a su inhibidor ikb de forma inactiva. tras la se\u00f1alizaci\u00f3n iniciada por tnf-alpha, ikb es modificado (fosforilado y poliubiquitinizado) lo que conduce a la liberaci\u00f3n de nf-kb que se dirige al n\u00facleo donde activa la transcripci\u00f3n de aquellos genes que contengan secuencias de uni\u00f3n a nf-kb en sus promotores.  recientemente, se ha demostrado que la enzima poli-adp-ribosa polimerasa-1 (parp-1) est\u00e1 involucrada en la alteraci\u00f3n funcional de la c\u00e9lula endotelial observada en varias condiciones fisiopatol\u00f3gicas como son la reperfusi\u00f3n, el shock endot\u00f3xico, la diabetes o el envejecimiento. Parp-1 es una enzima nuclear (ec 2.4.2.30) altamente conservada, con un dominio de uni\u00f3n al dna que recon<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de la expresion genica mediada por poli adp ribosa polimerasa 1 en la celula endotelial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de la expresion genica mediada por poli adp ribosa polimerasa 1 en la celula endotelial <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Carrillo Redondo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Yelamos Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: victoriano Francisco (secretario) Mulero mendez <\/li>\n<li>Mar\u00eda del pilar Garc\u00eda pe\u00f1arrubia (vocal)<\/li>\n<li>Javier Oliver pozo (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Carrillo Redondo La alteraci\u00f3n funcional de la c\u00e9lula endotelial es un fen\u00f3meno importante que ocurre de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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