{"id":69917,"date":"2004-10-09T00:00:00","date_gmt":"2004-10-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/induccion-de-muerte-apoptotica-y-necrotica-en-celulas-promonoca%c2%adticas-regulacion-por-oxidacion-y-protea%c2%adnas-de-estres\/"},"modified":"2004-10-09T00:00:00","modified_gmt":"2004-10-09T00:00:00","slug":"induccion-de-muerte-apoptotica-y-necrotica-en-celulas-promonoca%c2%adticas-regulacion-por-oxidacion-y-protea%c2%adnas-de-estres","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/induccion-de-muerte-apoptotica-y-necrotica-en-celulas-promonoca%c2%adticas-regulacion-por-oxidacion-y-protea%c2%adnas-de-estres\/","title":{"rendered":"Inducci\u00f3n de muerte apopt\u00f3tica y necr\u00f3tica en c\u00e9lulas promonoc\u00edticas: regulaci\u00f3n por oxidaci\u00f3n y prote\u00ednas de estr\u00e9s."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Sancho Andr\u00e9s <\/strong><\/h2>\n<p>El cadmio es un metal pesado que constituye uno de los principales contaminantes ambientales y ocupacionales y, adem\u00e1s de causar intoxicaciones agudas, est\u00e1 incluido en el grupo i de carcin\u00f3genos humanos.  este metal ejerce numerosos efectos da\u00f1inos en las c\u00e9lulas y, por ello, induce muerte celular en forma de apoptosis y de necrosis, siendo la apoptosis la forma predominante. La funci\u00f3n principal de la apoptosis en un organismo pluricelular es la eliminaci\u00f3n selectiva de una c\u00e9lula, evitando el da\u00f1o a las c\u00e9lulas adyacentes. Es, por tanto, muy importante el conocimiento de los mecanismos que en \u00faltimo t\u00e9rmino deciden la adopci\u00f3n de uno u otro modo de muerte celular. En esta tesis doctoral, adem\u00e1s de un estudio en profundidad de la v\u00eda de apoptosis inducida por  cadmio, se analizan los factores responsables de la generaci\u00f3n de necrosis en c\u00e9lulas tratadas con cadmio en condiciones de supresi\u00f3n de glutation. La aparici\u00f3n de necrosis se debe a una combinaci\u00f3n de factores dependientes e independientes de la acumulaci\u00f3n de especies reactivas del ox\u00edgeno derivada de la falta de glutation, principal defensa antioxidante celular.  los agentes antioxidantes constituyen una de las principales defensas del organismo frente a la oxidaci\u00f3n producida en la cadena respiratoria mitocondrial y frente al estr\u00e9s oxidativo. En esta tesis doctoral se muestra por primera vez el efecto de un antioxidante, la catalasa, como potenciador de la citotoxicidad de inductores t\u00edpicos de estr\u00e9s, como el cadmio y el choque t\u00e9rmico. Este fen\u00f3meno se produce por una inhibici\u00f3n de la respuesta de estr\u00e9s inducida por estos agentes, lo que sugiere la importancia de la oxidaci\u00f3n celular en la modulaci\u00f3n de la respuesta de estr\u00e9s.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inducci\u00f3n de muerte apopt\u00f3tica y necr\u00f3tica en c\u00e9lulas promonoc\u00edticas: regulaci\u00f3n por oxidaci\u00f3n y prote\u00ednas de estr\u00e9s.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inducci\u00f3n de muerte apopt\u00f3tica y necr\u00f3tica en c\u00e9lulas promonoc\u00edticas: regulaci\u00f3n por oxidaci\u00f3n y prote\u00ednas de estr\u00e9s. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Sancho Andr\u00e9s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Patricio Aller Tresguerres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  antonia Lizarbe  iracheta <\/li>\n<li>consuelo Calle Garc\u00eda (vocal)<\/li>\n<li>carmen Navarro ranninger (vocal)<\/li>\n<li>Francisco Javier Lucio caza\u00f1a (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Sancho Andr\u00e9s El cadmio es un metal pesado que constituye uno de los principales contaminantes ambientales 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