{"id":70015,"date":"2018-03-09T23:14:33","date_gmt":"2018-03-09T23:14:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inactivacion-de-farmacos-antineoplasicos-por-enzimas-tumorales-expresion-y-regulacion-de-citocromos-p-450-en-cancer-colorrectal\/"},"modified":"2018-03-09T23:14:33","modified_gmt":"2018-03-09T23:14:33","slug":"inactivacion-de-farmacos-antineoplasicos-por-enzimas-tumorales-expresion-y-regulacion-de-citocromos-p-450-en-cancer-colorrectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/extremadura\/inactivacion-de-farmacos-antineoplasicos-por-enzimas-tumorales-expresion-y-regulacion-de-citocromos-p-450-en-cancer-colorrectal\/","title":{"rendered":"Inactivaci\u00f3n de f\u00e1rmacos antineopl\u00e1sicos por enzimas tumorales: expresi\u00f3n y regulaci\u00f3n de citocromos p-450 en c\u00e1ncer colorrectal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Mar\u00eda Pizarro Gomez <\/strong><\/h2>\n<p>Uno de los fen\u00f3menos m\u00e1s importantes en la evoluci\u00f3n y en la esperanza de vida delos pacientes con c\u00e1ncer es el grado de sensibilidad del tumor al tratamiento quimioter\u00e1pico. La eficacia terap\u00e9utica est\u00e1 condicionada por la sensibilidad tumoral, que suele ir disminuyendo al o largo de los ciclos de quimioterapia. De este modo antineopl\u00e1sicos que se revelan inicialmente eficacias, van perdiendo progresivamente efectividad debido a mecanismos de resistencia adquiridos por las c\u00e9lulas tumorales. este trabajo explora un mecanismos de resistencia tumoral desconocido hasta el momento, cuyo an\u00e1lisis ha sido posible a partir delos avances en el genoma humano. Este mecanismo de resistencia condiciona la eficacia antitumoral de un grupo de quimioter\u00e1picos de amplio uso en diversos tipos de c\u00e1ncer, los texanos, y probablemente afecta a muchos otros quimioter\u00e1picos.     el principio de este mecanismo de resistencia consiste en la expresi\u00f3n en c\u00e9lulas tumorales de genes que codifican enzimas inactivadoras de quimioter\u00e1picos. La inactivaci\u00f3n de los quimioter\u00e1picos tiene lugar en el interior de la c\u00e9lula tumoral y se lleva a cabo por enzimas tumorales similares a las enzimas que habitualmente intervienen en el metabolismo de estos f\u00e1rmacos en el h\u00edgado sano. en este trabajo de investigaic\u00f3n se describe por primera vez la presencia de esas enzimas inactivadoras en c\u00e9lulas tumorales, se analiza la variabilidad de los genes que las codifican, las propiedades de esas enzimas y su capacidad para inactivar los quimioter\u00e1picos. Se investiga adem\u00e1s la posibilidad de eliminar la resistencia que dichas enzimas confieren a las c\u00e9lulas tumorales utilizando inhibidores enzim\u00e1ticos espec\u00edficos, ya analizando los fen\u00f3menos de inducci\u00f3n de la expresi\u00f3n de enzimas inactivadoras de antineopl\u00e1sicos.     en el trabajo se obtienen las siguientes conclusiones:     1,- las c\u00e9lulas tumorales tienen capacidad de expresar enzimas inactivadoras en cantidad suficiente<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inactivaci\u00f3n de f\u00e1rmacos antineopl\u00e1sicos por enzimas tumorales: expresi\u00f3n y regulaci\u00f3n de citocromos p-450 en c\u00e1ncer colorrectal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inactivaci\u00f3n de f\u00e1rmacos antineopl\u00e1sicos por enzimas tumorales: expresi\u00f3n y regulaci\u00f3n de citocromos p-450 en c\u00e1ncer colorrectal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Mar\u00eda Pizarro Gomez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garc\u00eda Mart\u00edn Mar\u00eda  Elena<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Mi\u00f1ano s\u00e1nchez Francisco javier <\/li>\n<li>ramiro Jover atienza (vocal)<\/li>\n<li>Mar\u00eda Elena Guzm\u00e1n caba\u00f1as (vocal)<\/li>\n<li> Carrillo norte Juan  Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Mar\u00eda Pizarro Gomez Uno de los fen\u00f3menos m\u00e1s importantes en la evoluci\u00f3n y en la esperanza [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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