{"id":7002,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/hepatitis-c-viremia-en-sujetos-asintomaticos-y-en-pacientes-con-hepatitis-cronica-tratados-con-interferon-alfa-2-b-recombinante\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"hepatitis-c-viremia-en-sujetos-asintomaticos-y-en-pacientes-con-hepatitis-cronica-tratados-con-interferon-alfa-2-b-recombinante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/hepatitis-c-viremia-en-sujetos-asintomaticos-y-en-pacientes-con-hepatitis-cronica-tratados-con-interferon-alfa-2-b-recombinante\/","title":{"rendered":"Hepatitis c: viremia en sujetos asintomaticos y en pacientes con hepatitis cronica tratados con interferon alfa 2-b-recombinante."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Suarez Leiva <\/strong><\/h2>\n<p>En pacientes con infeccion cronica por vhc (hcc) el unico tratamiento que se ha mostrado util es el interferon (ifn), aunque no mas de un 25% se benefician a largo plazo del mismo (rcm) ademas, no esta claro si la rcm va acompa\u00f1ada de la desaparicion del virus. Hemos estudiado 51 pacientes con hcc sometidos a tratamiento con ifn-alfa 2b, y 22 donantes de sangre asintomaticos con anticuerpos anti vhc y normalidad bioquimica que aceptaron la realizacion de una biopsia hepatica. El 17,6% de los pacientes con hcc obtuvieron rcm, el 33,3% rcnm, el 25,5% rp y el 23,5 % nr. El 77,6% estaban infectados por el genotipo ii, el 14,3 % por el i, el 6,1 % no se clasificaron, y el 2 % por el iii. Durante el tratamiento, la viremia fue negativa en la 8 semana en todos pacientes con rcm, sin embargo, 6 meses despues de finalizado el tratamiento en 3 pacientes con rcm se detecto de nuevo rna-vhc a pesar de mantener las transaminasas normales. El numero de pacientes con anticuerpos anti core vhc igm negativos en la muestra basal fue inferior en los que obtuvieron rcm (11,1%; p&lt;0.01). El analisis multivariado de regresion logistica encontro un modelo de dos variables (ferritina y anti-core vhc igm) para predecir la respuesta completa (rcm+rcnm). De los 22 donantes de sangre el 45,5% tenia hepatitis cronica (hc) y en el 54,5% restante la histolog\u00eda era normal. Se detecto rna-vhc y en el 58,3% con biopsia normal (probablemente portadores \u00abasintomaticos\u00bb).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hepatitis c: viremia en sujetos asintomaticos y en pacientes con hepatitis cronica tratados con interferon alfa 2-b-recombinante.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hepatitis c: viremia en sujetos asintomaticos y en pacientes con hepatitis cronica tratados con interferon alfa 2-b-recombinante. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Suarez Leiva <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Mendez Garcia Francisco Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Hardisson Rumeu <\/li>\n<li>Dolores Maluenda Colomer (vocal)<\/li>\n<li>Agustin Caro Paton Gomez (vocal)<\/li>\n<li>Luis Rodrigo Saez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Suarez Leiva En pacientes con infeccion cronica por vhc (hcc) el unico tratamiento que se ha [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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