{"id":70026,"date":"2018-03-09T23:14:33","date_gmt":"2018-03-09T23:14:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacocinetico-de-la-amiodarona-en-la-rata\/"},"modified":"2018-03-09T23:14:33","modified_gmt":"2018-03-09T23:14:33","slug":"estudio-farmacocinetico-de-la-amiodarona-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacocinetico-de-la-amiodarona-en-la-rata\/","title":{"rendered":"Estudio farmacocinetico de la amiodarona en la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduardo Martin Campos Moreno <\/strong><\/h2>\n<p>En la presente memoria se ha abordado el estudio de la farmacocin\u00e9tica de la amiodarona y la caracterizaci\u00f3n del proceso de disposici\u00f3n, con el fin de poner de manifiesto la p\u00e9rdida de linealidad, cuando se administra el f\u00e1rmaco a distintas dosis crecientes y mediante distintos m\u00e9todos de administraci\u00f3n intravenosa.        Se han realizado ensayos \u00abin vivo\u00bb utilizando como modelo animal la rata. El dise\u00f1o experimental ha sido totalmente aleatorio, administrando mediante bolus iv dosis de 5, 12,5, 25 y 50 mg de amiodarona. del mismo modo dosis de 55, 60 y 50 mg se han administrado mediante perfusi\u00f3n o combinaci\u00f3n de bolus y perfusi\u00f3n iv.     Para facilitar la toma de muestras plasm\u00e1ticas se ha recurrido a una t\u00e9cnica quir\u00fargica consistente en la implantaci\u00f3n de un cat\u00e9ter de forma permanente en la vena yugular y de dos cat\u00e9teres en el caso de administraci\u00f3n del f\u00e1rmaco mediante perfusi\u00f3n iv. Durante la realizaci\u00f3n del ensayo los animales tienen libre acceso al alimento y agua.        Para la valoraci\u00f3n de la amiodarona en las muestras plasm\u00e1ticas se ha utilizado la cromatograf\u00eda l\u00edquida de alta eficacia. esta t\u00e9cnica requiere la extracci\u00f3n previa del f\u00e1rmaco utilizando una secuencia de extracci\u00f3n mediante un disolvente org\u00e1nico. Este m\u00e9todo de valoraci\u00f3n ha sido convenientemente validado en cuanto a exactitud y precisi\u00f3n.       A continuaci\u00f3n, se ha procedido al ajuste al modelo bicompartimental de los valores experimentales obtenidos, mediante dos m\u00e9todos de estimaci\u00f3n de dos etapas, m\u00e9todo de m\u00ednimos cuadrados ponderados (winnonlin) y m\u00e1xima verosimilitud (adaptii). Tambi\u00e9n se ha realizado un tratamiento no compartimental, mediante el m\u00e9todo trapezoidal. En todos los casos se han determinado los par\u00e1metros farmacocin\u00e9ticos correspondientes y se han comparado estad\u00edsticamente entre ellos para poner de manifiesto posibles diferencias significativas. del mismo modo, se ha abordado comparaciones de l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacocinetico de la amiodarona en la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacocinetico de la amiodarona en la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduardo Martin Campos Moreno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente German Casabo Alos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: victor Jimenez torres <\/li>\n<li>gerardo Anton fos (vocal)<\/li>\n<li> Morcillo sanchez esteban j. (vocal)<\/li>\n<li>concepci\u00f3n Peraire guitart (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduardo Martin Campos Moreno En la presente memoria se ha abordado el estudio de la farmacocin\u00e9tica de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[14228,153073,61343,50978,12342,3309],"class_list":["post-70026","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-concepcion-peraire-guitart","tag-eduardo-martin-campos-moreno","tag-gerardo-anton-fos","tag-morcillo-sanchez-esteban-j","tag-vicente-german-casabo-alos","tag-victor-jimenez-torres"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70026","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=70026"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70026\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=70026"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=70026"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=70026"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}