{"id":70074,"date":"2018-03-09T23:14:33","date_gmt":"2018-03-09T23:14:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-transcripcional-de-la-expresion-de-los-genes-ntp1-y-tps1-inducida-por-estres-en-schizosaccharomyces-pombe\/"},"modified":"2018-03-09T23:14:33","modified_gmt":"2018-03-09T23:14:33","slug":"regulacion-transcripcional-de-la-expresion-de-los-genes-ntp1-y-tps1-inducida-por-estres-en-schizosaccharomyces-pombe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/regulacion-transcripcional-de-la-expresion-de-los-genes-ntp1-y-tps1-inducida-por-estres-en-schizosaccharomyces-pombe\/","title":{"rendered":"Regulacion transcripcional de la expresion de los genes ntp1 y tps1 inducida por estres en schizosaccharomyces pombe"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Paredes Garcia M. Vanessa <\/strong><\/h2>\n<p>En la levadura con fisi\u00f3n schizosaccharomyces pombe la ruta de map kinasas activable por estr\u00e9s , hom\u00f3loga a la ruta sapk de eucariotas superiores juega un papel importante en la transmisi\u00f3n de se\u00f1ales extracelulares al nucleo celular, provocando cambios significativos en los patrones de expresi\u00f3n g\u00e9nica. El elemento central de la ruta es la map kinasa sty1p que es activable en respuesta a m\u00faltiples condiciones de estr\u00e9s, fosforil\u00e1ndose y asoci\u00e1ndose in vivo al factor transcripcional atf1p. En las levaduras, la respuesta frente a cambios medioambientales provoca un aumento en la s\u00edntesis de trehalosa un disac\u00e1rido no reductor que act\u00faa como carbohidrato de reserva y como metabolito de estr\u00e9s. En s. Pombe la expresi\u00f3n de los genes ntp1+ y tps1+ que codifican, respectivamente los enzimas trehalasa y la trehalosa 6p sintetasa, implicados en la s\u00edntesis y degradaci\u00f3n de la trehalosa se inducen transcripcionalemente en respuesta a m\u00faltiples estreses de manera preferente a trav\u00e9s de la ruta sapk y de dos de sus efectores, atf1p y pap1p. En condiciones de choque t\u00e9rmico y osm\u00f3tico, la map kinasa sty1p regula parcialmente la activaci\u00f3n transcripcional por medio de atf1p, mientras que atf1p y pa1p son los responsables de la inducci\u00f3n en condiciones de estr\u00e9s oxidativo de dosis alta. La mapk  sty1p regula, de manera independiente a atf1p y\/o pap1p, la activaci\u00f3n post-traduccional de la trehalasa neutra y la s\u00edntesis de trehalosa en condiciones de estr\u00e9s osm\u00f3tico y oxidativo, pero no durante estr\u00e9s t\u00e9rmico.  La ruta sapk es epist\u00e1tica sobre pka1p, prote\u00edna kinasa que activa por fosforilaci\u00f3n a la trehalasa neutra, en la activaci\u00f3n transcripcional de ntp1+ y tps1+ mediada por estr\u00e9s , aunque pka1p reprime los niveles basales de expresi\u00f3n de ambos genes en presencia de glucosa. El factor transcripcional rst2p no es responsable de la represi\u00f3n de los niveles basales de expresi\u00f3n de ntp1+ debida a pka1p.  la uni\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion transcripcional de la expresion de los genes ntp1 y tps1 inducida por estres en schizosaccharomyces pombe<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion transcripcional de la expresion de los genes ntp1 y tps1 inducida por estres en schizosaccharomyces pombe <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Paredes Garcia M. Vanessa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Cansado Vizoso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: germ\u00e1n Larriba calle <\/li>\n<li>victoriano Garre mula (vocal)<\/li>\n<li>franscisco Garcia carmona (vocal)<\/li>\n<li>Mar\u00eda  del pilar Perez gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paredes Garcia M. Vanessa En la levadura con fisi\u00f3n schizosaccharomyces pombe la ruta de map kinasas activable [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8235],"tags":[153160,2980,62193,9869,153159,8464],"class_list":["post-70074","post","type-post","status-publish","format-standard","hentry","category-murcia","tag-franscisco-garcia-carmona","tag-german-larriba-calle","tag-jose-cansado-vizoso","tag-maria-del-pilar-perez-gonzalez","tag-paredes-garcia-m-vanessa","tag-victoriano-garre-mula"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70074","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=70074"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70074\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=70074"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=70074"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=70074"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}