{"id":70085,"date":"2018-03-09T23:14:37","date_gmt":"2018-03-09T23:14:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reparacion-de-lesiones-excitotoxicas-desmielinazantes-con-mitogenos-de-los-precursores-oligodendrogliales\/"},"modified":"2018-03-09T23:14:37","modified_gmt":"2018-03-09T23:14:37","slug":"reparacion-de-lesiones-excitotoxicas-desmielinazantes-con-mitogenos-de-los-precursores-oligodendrogliales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/reparacion-de-lesiones-excitotoxicas-desmielinazantes-con-mitogenos-de-los-precursores-oligodendrogliales\/","title":{"rendered":"Reparacion de lesiones excitotoxicas desmielinazantes con mitogenos de los precursores oligodendrogliales"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Soto Del Castillo Alvaro <\/strong><\/h2>\n<p>Las enfermedades desmielinizantes, entre ellas la esclerosis m\u00faltiple, afectan al 0,1-0,2% de la poblaci\u00f3n. A fecha de hoy, s\u00f3lo existen remedios paliativos para abordar el problema y ni siquiera se ha identificado el modo de promover la remielinizaci\u00f3n in vivo frente a estas lesiones.  el desconocimiento de la etiopatolog\u00eda de las enfermedades desmielinizantes requiere el empleo de modelos experimentales en animales. Uno de ellos se basa en la vulnerabilidad de los oligoendrocitos a las se\u00f1ales excitadoras glutamat\u00e9rgicas. Estas substancias al sobreactivar los receptores glutamat\u00e9rgicos del tipo ampa y kainato, presentes en los oligodendrocitos, provocan su muerte tanto in vitro como in vivo. In vivo, las lesiones producidas en nervio \u00f3ptico producen desmielinizaci\u00f3n e nflamaci\u00f3n, y da lugar a placas con propiedades que rememoran las observadas en la esclerosis m\u00faltiple.  el proyecto presentado tiene como objetivo final el estudio de la recuperaci\u00f3n de lesiones desmielinizantes que previamente han sido provocadas mediante excitotoxicidad. Adem\u00e1s, por este motivo se hace indispensable el an\u00e1lisis y estudio del desarrollo de los precursores oligodendrogliales y todo su linaje celular mediante el empleo de mit\u00f3genos.  por todo ello, se han empleado t\u00e9cnicas inmunohistoqu\u00edmicas y electrofisiol\u00f3gicas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Reparacion de lesiones excitotoxicas desmielinazantes con mitogenos de los precursores oligodendrogliales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Reparacion de lesiones excitotoxicas desmielinazantes con mitogenos de los precursores oligodendrogliales <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Soto Del Castillo Alvaro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Matute Almau<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Lafuente sanchez Jos\u00e9 vicente <\/li>\n<li>alfonso Fairen carrion (vocal)<\/li>\n<li>Francisco Gonzalez garcia (vocal)<\/li>\n<li>paola Bovolenta nicolao (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Soto Del Castillo Alvaro Las enfermedades desmielinizantes, entre ellas la esclerosis m\u00faltiple, afectan al 0,1-0,2% de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909],"tags":[14563,10024,1696,47284,29565,153178],"class_list":["post-70085","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","tag-alfonso-fairen-carrion","tag-carlos-matute-almau","tag-francisco-gonzalez-garcia","tag-lafuente-sanchez-jose-vicente","tag-paola-bovolenta-nicolao","tag-soto-del-castillo-alvaro"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=70085"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70085\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=70085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=70085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=70085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}