{"id":70088,"date":"2018-03-09T23:14:37","date_gmt":"2018-03-09T23:14:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-glucoquinasa-en-musculo-esqueletico-papel-en-la-contrarrestacion-de-la-diabetes-mellitus\/"},"modified":"2018-03-09T23:14:37","modified_gmt":"2018-03-09T23:14:37","slug":"expresion-de-glucoquinasa-en-musculo-esqueletico-papel-en-la-contrarrestacion-de-la-diabetes-mellitus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-glucoquinasa-en-musculo-esqueletico-papel-en-la-contrarrestacion-de-la-diabetes-mellitus\/","title":{"rendered":"Expresi\u00f3n de glucoquinasa en m\u00fasculo esquel\u00e9tico: papel en la contrarrestaci\u00f3n de la diabetes mellitus"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Ontiveros Gonz\u00e1lez <\/strong><\/h2>\n<p>La diabetes mellitus es una enfermedad metab\u00f3lica muy frecuente, que comprende una gran variedad de s\u00edndromes con diferentes etiolog\u00edas y que afecta en total a un 2-7% de la poblaci\u00f3n mundial. Esta enfermedad se caracteriza, b\u00e1sicamente, por una hiperglucemia debido a la falta de insulina o a una alteraci\u00f3n en la acci\u00f3n de la hormona. En nuestro laboratorio estamos desarrollando aproximaciones para reducir la hiperglucemia diab\u00e9tica mediante la manipulaci\u00f3n de tejido sextrapancre\u00e1ticos con el fin de que capten glucosa.  el m\u00fasculo esquel\u00e9tico es el principal tejido implicado en la captaci\u00f3n de glucosa sanguinea despu\u00e9s de una ingesta, eliminado alrededor del 75% del azucar. El tejido muscular capta glucosa por difusi\u00f3n facilitada de forma dependiente e independiente de la insulina. Por tanto, como consecuencia de la falta de insulina en la diabetes de tipo 1 o de la resistencia a la hormona en la diabetes de tipo 2, el musculo esquel\u00e9tico es incapaz de captar glucosa de la sangre. En nuestro laboratorio se hab\u00edan generado ratones transg\u00e9nicos que expresan la enzima hep\u00e1tica glucoquinasa en m\u00fasculo esquel\u00e9tico. Estos ratones presentan un incremento en la captaci\u00f3n y utilizaci\u00f3n de la glucosa, pero permanecen hipergluc\u00e9micos en alimentaci\u00f3n  tras un tratamiento con stz. Esto podr\u00eda ser debido a una alteraci\u00f3n en el transporte de la glucosa hacia el interior de la c\u00e9lula muscular. As\u00ed, en este trabajo hemos obtenido ratones transg\u00e9nicos que expresan ambos, el transportador glut2 y la enzima gk, en m\u00fasculo esquel\u00e9tico, con la finalidad de incrementar el transporte y la fosforilaci\u00f3n de glucosa. Esto se realiz\u00f3 para estudiar si la coexpresi\u00f3n de estas dos prote\u00ednas resultaba en una normalizac\u00f3n de la hiperglucemia diab\u00e9tica. Sin embargo, los resultados obtenidos indican que la expresi\u00f3n de glut2 en m\u00fasculo esquel\u00e9tico de ratone smlc\/gk tratados con stz no mejora los resultados obtenidos con ratones que ex<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n de glucoquinasa en m\u00fasculo esquel\u00e9tico: papel en la contrarrestaci\u00f3n de la diabetes mellitus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n de glucoquinasa en m\u00fasculo esquel\u00e9tico: papel en la contrarrestaci\u00f3n de la diabetes mellitus <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Ontiveros Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fatima Bosch Tubert<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: victoria (secretario) Nogu\u00e9s bara <\/li>\n<li>laurent Gros (vocal)<\/li>\n<li>jordi Barquinero ma\u00f1ez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Ontiveros Gonz\u00e1lez La diabetes mellitus es una enfermedad metab\u00f3lica muy frecuente, que comprende una gran variedad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[14073,39636,153183,153181,153182],"class_list":["post-70088","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-fatima-bosch-tubert","tag-jordi-barquinero-manez","tag-laurent-gros","tag-maria-ontiveros-gonzalez","tag-victoria-secretario-nogues-bara"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70088","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=70088"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70088\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=70088"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=70088"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=70088"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}