{"id":70114,"date":"2018-03-09T23:14:37","date_gmt":"2018-03-09T23:14:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-inmunofenota%c2%adpico-de-los-mastocitos-de-medula-osea-en-las-mastocitosis-pediatricas\/"},"modified":"2018-03-09T23:14:37","modified_gmt":"2018-03-09T23:14:37","slug":"estudio-inmunofenota%c2%adpico-de-los-mastocitos-de-medula-osea-en-las-mastocitosis-pediatricas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/estudio-inmunofenota%c2%adpico-de-los-mastocitos-de-medula-osea-en-las-mastocitosis-pediatricas\/","title":{"rendered":"Estudio inmunofenot\u00edpico de los mastocitos de m\u00e9dula \u00f3sea en las mastocitosis pedi\u00e1tricas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Herrero Mart\u00edn <\/strong><\/h2>\n<p>1. La citometr\u00eda de flujo es una t\u00e9cnica sensible, espec\u00edfica y reproducible para la identifaci\u00f3n, el recuento y la caracterizaci\u00f3n inmunofenot\u00edpica los mastocitos de medula \u00f3sea en las mastocitosis pedi\u00e1tricas.  2. En 7 de los 27 casos (27%) incluidos en el presente estudio, la citometr\u00eda de flujo ha permitido demostrar la presencia de un inmunofenotipo aberrante en los mastocitos de m\u00e9dula \u00f3sea caracterizado por un patr\u00f3n de expresi\u00f3n antig\u00e9nica similar al encontrado en las mastocitosis sist\u00e9micas del adulto: expresi\u00f3n de los ant\u00edgenos cd25 y cd2 (\u00e9ste en 6 de 7 casos), junto con una sobre expresi\u00f3n de cd35 y cd69. En un caso el inmunofenotipo de los mastocitos de m\u00e9dula \u00f3sea era normal pero su porcentaje era muy superior al encontrado en m\u00e9dula \u00f3sea normal. Sobre la base de estos hallazgos, se consider\u00f3 que en 8 de los 27 casos incluidos en este estudio (29,6%) exist\u00eda una afectaci\u00f3n de la m\u00e9dula \u00f3sea.  3. En 10 de 23 casos valorables (43,4%) se detect\u00f3 la presencia de una mutaci\u00f3n del c-kit en los mastocitos de la piel, siendo en 5 casos (22%) la mutaci\u00f3n activante asp-816val.  4. Al estudiar la correlaci\u00f3n entre el inmunofenotipo de los mastocitos de m\u00e9dula \u00f3sea y otros par\u00e1metros diagn\u00f3sticos, hemos podido comprobar que en todos aquellos casos cuyos mastocitos presentaban un inmunofenotipo anormal la morfolog\u00eda de los mastocitos medulares era at\u00edpica. Por el contrario, un inmunofenotipo normal se asociaba siempre con una morfolog\u00eda mastocitaria tambi\u00e9n normal. Asimismo, la incidencia de la mutaci\u00f3n activante asp-816val del c-kit era mayor en los casos con inmunofenotipo aberrante (4 de 7 -57%) que en aquellos cuyo inmunofenotipo era normal (1 de16 -6%).  5. No se ha podido establecer una relaci\u00f3n entre la evoluci\u00f3n de la enfermedad y la presencia o ausencia de mutaciones activantes del c-kit. Sin embargo, el porcentaje de casos con mejor\u00eda o regresi\u00f3n total de la enfermedad parece m\u00e1s<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio inmunofenot\u00edpico de los mastocitos de m\u00e9dula \u00f3sea en las mastocitosis pedi\u00e1tricas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio inmunofenot\u00edpico de los mastocitos de m\u00e9dula \u00f3sea en las mastocitosis pedi\u00e1tricas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Herrero Mart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Escribano Mora<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: melchor Alvarez de mon soto <\/li>\n<li> Morales sanz M\u00aa dolores (vocal)<\/li>\n<li>paloma Ramos guill\u00e9n (vocal)<\/li>\n<li>Antonio Torrelo fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Herrero Mart\u00edn 1. La citometr\u00eda de flujo es una t\u00e9cnica sensible, espec\u00edfica y reproducible para la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426],"tags":[45407,41390,14431,153238,90637,153237],"class_list":["post-70114","post","type-post","status-publish","format-standard","hentry","category-alcala","tag-antonio-torrelo-fernandez","tag-luis-escribano-mora","tag-melchor-alvarez-de-mon-soto","tag-morales-sanz-ma-dolores","tag-paloma-ramos-guillen","tag-sonia-herrero-martin"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70114","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=70114"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70114\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=70114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=70114"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=70114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}