{"id":70182,"date":"2018-03-09T23:14:41","date_gmt":"2018-03-09T23:14:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-del-gen-del-receptor-de-gnrh-r-gnrh-en-el-desarrollo-puberal-y-el-envejecimiento-de-la-rata-wistar-y-en-el-modelo-hipogonadal-de-la-rata-zucker\/"},"modified":"2018-03-09T23:14:41","modified_gmt":"2018-03-09T23:14:41","slug":"expresion-del-gen-del-receptor-de-gnrh-r-gnrh-en-el-desarrollo-puberal-y-el-envejecimiento-de-la-rata-wistar-y-en-el-modelo-hipogonadal-de-la-rata-zucker","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-del-gen-del-receptor-de-gnrh-r-gnrh-en-el-desarrollo-puberal-y-el-envejecimiento-de-la-rata-wistar-y-en-el-modelo-hipogonadal-de-la-rata-zucker\/","title":{"rendered":"Expresi\u00f3n del gen del receptor de gnrh (r-gnrh) en el desarrollo puberal y el envejecimiento de la rata wistar y en el modelo hipogonadal de la rata zucker"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Helena Zapatero Caballero <\/strong><\/h2>\n<p>La adecuada expresi\u00f3n del gen del receptor de gnrh (r-gnrh) en las c\u00e9lulas gonadotropas hipofisarias es cr\u00edtica para la se\u00f1alizaci\u00f3n de gnrh y, por tanto, para la liberaci\u00f3n de gonadotropinas y el desarrollo sexual. En este trabajo hemos estudiado la ontogenia de la expresi\u00f3n del gen de r-gnrh durante el desarrollo puberal de la rata wistar (macho y hembra) as\u00ed como los cambios que acontecen en el envejecimiento (macho). Adem\u00e1s, hemos estudiado la expresi\u00f3n hipofisaria de r-gnrh en un modelo descrito como hipogonadal: la rata obesa zucker.  hemos demostrado que la expresi\u00f3n del gen de r-gnrh en la rata wistar macho aumenta progesivamente desde el d\u00eda 5 postnatal, hasta el d\u00eda 25, con una aceleraci\u00f3n para alcanzar m\u00e1ximos el d\u00eda 35, inicio de la pubertad en machos. la expresi\u00f3n de las subunidades beta de las gonadotropins sigue un patr\u00f3n similar a la del receptor pero retrasada temporalmente. Adem\u00e1s, hemos demostrado la existencia de un claro dimorfismo sexual, ya que los datos de la ontogenia de la expresi\u00f3n del gen de r-gnrh en la rata hembra nos muestra un pico temprano a los 20 d\u00edas, con descenso posterior, tambi\u00e9n respaldo por la expresi\u00f3n de las subnidades beta de las gonadotropinas. En ambos casos, la expresi\u00f3n de la subunidad alfa, com\u00fan a lh y fsh, presenta un patr\u00f3n de expresi\u00f3n distinto, lo que sugiere su regulaci\u00f3n por otras se\u00f1ales distintas de gnrh. Cetrorelix, antagonista de gnrh, abole completamente la expresi\u00f3n de los genes implicados en el desarrollo puberal, r-gnrh, lhbeta y fshbeta, en ambos sexos. Ello demuestra que su expresi\u00f3n depende de gnrh hipotal\u00e1mico. sin embargo, no modifica la expresi\u00f3n de la subunidad alfa, lo que reafirma su regulaci\u00f3n independiente de gnrh.  hemos demostrado un descenso de los niveles de arnm de r-gnrh en el envejecimiento que puede contribuir al hipogonadismo hipogonadotropo de este periodo.  tambi\u00e9n hemos estudiado la expresi\u00f3n del gen de r-gnrh en la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n del gen del receptor de gnrh (r-gnrh) en el desarrollo puberal y el envejecimiento de la rata wistar y en el modelo hipogonadal de la rata zucker<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n del gen del receptor de gnrh (r-gnrh) en el desarrollo puberal y el envejecimiento de la rata wistar y en el modelo hipogonadal de la rata zucker <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Helena Zapatero Caballero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gumersindo Fernandez Vazquez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: aniceto Luis Charro salgado <\/li>\n<li> Esponda fernandez pedro hernan (vocal)<\/li>\n<li>enrique Aguilar benitez de lugo (vocal)<\/li>\n<li> Ordas y santo tomas Juan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Helena Zapatero Caballero La adecuada expresi\u00f3n del gen del receptor de gnrh (r-gnrh) en las c\u00e9lulas gonadotropas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[6462,2380,14538,46309,153355,153356],"class_list":["post-70182","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-aniceto-luis-charro-salgado","tag-enrique-aguilar-benitez-de-lugo","tag-esponda-fernandez-pedro-hernan","tag-gumersindo-fernandez-vazquez","tag-helena-zapatero-caballero","tag-ordas-y-santo-tomas-juan"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70182","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=70182"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70182\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=70182"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=70182"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=70182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}