{"id":70232,"date":"2018-03-09T23:14:44","date_gmt":"2018-03-09T23:14:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevas-estrategias-antitromboticas-para-el-tratamiento-de-la-cardiopata%c2%ada-isquemica\/"},"modified":"2018-03-09T23:14:44","modified_gmt":"2018-03-09T23:14:44","slug":"nuevas-estrategias-antitromboticas-para-el-tratamiento-de-la-cardiopata%c2%ada-isquemica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevas-estrategias-antitromboticas-para-el-tratamiento-de-la-cardiopata%c2%ada-isquemica\/","title":{"rendered":"Nuevas estrategias antitromb\u00f3ticas para el tratamiento de la cardiopat\u00edaisqu\u00e9mica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gemma Vilahur Garcia <\/strong><\/h2>\n<p>A pesar de los beneficios obtenidos con los salicilatos y otros antitromb\u00f3ticos en la enfermedad isqu\u00e9mica coronaria, estos no erradican los eventos tromb\u00f3ticos. ello ha derivado en el desarrollo y evaluaci\u00f3n de nuevas estrategias antitromb\u00f3ticas.  esta tesis se centra en el estudio de las propiedades antiplaquetares\/antitromb\u00f3ticas de nuevos f\u00e1rmacos destiandos al tratamiento de la enfermedad aterotromb\u00f3tica, para esclarecer sus beneficios cl\u00ednicos. Para ello, se realiz\u00f3 el estudio de trombosis ex vivo desencadenada por substratos vasculares lesionados en condiciones de flujo controladas utilizando la c\u00e1mara badimon en el modelo experimental porcino despu\u00e9s del tratamiento (local, ora o intravenoso) con un inhibidor de la adhesi\u00f3n plaquetar (saratina) o tres donadores de \u00f3xido n\u00edtrico (no) (la419, la810 y la816). Tras anestesiar, heparinizar y cateterizar a los animales se estableci\u00f3 un circuito arteriovenoso en el que se interpuso la c\u00e1mara que conten\u00eda el substrato trombog\u00e9nico.  primero se evalu\u00f3 el efecto inhibidor de saratina (tratamiento local, 30 ug\/ml) sobre la trombosis desencadenada por pared ateroscler\u00f3tica humana. saratina redujo significativamente la deposici\u00f3n plaquetaria a velocidades de cizalladura t\u00edpicas de vasos ligeramente esten\u00f3ticos (800\/s), siendo m\u00e1s efectiva a mayor lesi\u00f3n.  en segundo lugar, se evalu\u00f3 el efecto de tres donadores de no administrados de manera cr\u00f3nica (la419: 0.9-1.8-3.6-5 mg\/kg durante 10 d\u00edas\/p.O.), Y agua (lab810 y la816: 6.6 nmols\/kg\/min, 2 h i.V.) En la trombosis desencadenada por pared porcina ligera y severamente da\u00f1ada.  el tratamiento con la419 (0.9 mg\/kg) redujo la deposici\u00f3n plaquetar  desencadenada por ambos tipos de lesi\u00f3n a velocidades de cizalladura t\u00edpica de vasos con stent  mientras que fueron necesarias dosis de 3.6 mg\/kg para reducir la formaci\u00f3n del trombo  a velocidades de cizalladura de vasos moderadamente esten\u00f3ticos. Ninguna dosis alter<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevas estrategias antitromb\u00f3ticas para el tratamiento de la cardiopat\u00edaisqu\u00e9mica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevas estrategias antitromb\u00f3ticas para el tratamiento de la cardiopat\u00edaisqu\u00e9mica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gemma Vilahur Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lina Badimon Maestro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Villaverde grote <\/li>\n<li>joan Mar\u00eda Cinca cuscullola (vocal)<\/li>\n<li>teresa Padr\u00f3 capmany (vocal)<\/li>\n<li>gin\u00e9s Escolar albadealejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gemma Vilahur Garcia A pesar de los beneficios obtenidos con los salicilatos y otros antitromb\u00f3ticos en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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