{"id":70241,"date":"2018-03-09T23:14:44","date_gmt":"2018-03-09T23:14:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-inmunohistoqua%c2%admica-del-cancer-de-prostata-localizado-valor-predictivo-de-pronostico\/"},"modified":"2018-03-09T23:14:44","modified_gmt":"2018-03-09T23:14:44","slug":"caracterizacion-inmunohistoqua%c2%admica-del-cancer-de-prostata-localizado-valor-predictivo-de-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/caracterizacion-inmunohistoqua%c2%admica-del-cancer-de-prostata-localizado-valor-predictivo-de-pronostico\/","title":{"rendered":"Caracterizaci\u00f3n inmunohistoqu\u00edmica del c\u00e1ncer de pr\u00f3stata localizado. valor predictivo de pron\u00f3stico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Carlos Tamayo Ruiz <\/strong><\/h2>\n<p>Introduccion  el c\u00e1ncer de pr\u00f3stata se ha convertido en los \u00faltimos a\u00f1os en un verdadero problema de salud en las sociedades occidentales. En eeuu es el c\u00e1ncer s\u00f3lido no cut\u00e1neo m\u00e1s frecuente de los varones. Adem\u00e1s, desde la introducci\u00f3n en la cl\u00ednica del psa se diagnostica en pacientes m\u00e1s j\u00f3venes y en estadios m\u00e1s precoces cuyo tratamiento suele consistir en la prostatectom\u00eda radical. se sabe que el 20-30% de estos casos van a recidivar en el plazo de 5 a\u00f1os, pero los factores pron\u00f3stico conocidos son imperfectos.  hipotesis y objetivos  la evoluci\u00f3n en el conocimiento de la biolog\u00eda molecular ha permitido identificar mol\u00e9culas implicadas en el desarrollo o control de la divisi\u00f3n de las c\u00e9lulas tumorales que pueden ser identificadas mediante t\u00e9cnicas de inmunohistoqu\u00edmica. Nos proponemos valorar la inmunoexpresi\u00f3n de pcna, ki-67, p21 y bcl-2 en el c\u00e1ncer de pr\u00f3stata localizado y establecer su valor pron\u00f3stico en los casos sometidos a prostatectom\u00eda radical.  material y metodos  se llev\u00f3 a cabo un estudio retrospectivo en el que se incluyeron pacientes diagnosticados de c\u00e1ncer de pr\u00f3stata localizado, sometidos a una prostatectom\u00eda radical, que no recibieron radioterapia ni hormonoterapia ni antes ni despu\u00e9s de la cirug\u00eda, que presentaron, al menos, una determinaci\u00f3n s\u00e9rica de psa indetectable en el postoperatorio y con un seguimiento m\u00ednimo de 24 meses en ausencia de recidiva. Se evaluaron los factores pron\u00f3stico cl\u00e1sicos: estadio patol\u00f3gico, grado histol\u00f3gico seg\u00fan gleason, psa preoperatorio y m\u00e1rgenes quir\u00fargicos. Se valor\u00f3 la inmunoexpresi\u00f3n de pcna, ki-67, p21 y bcl-2; y todos se relacionaron con la recidiva bioqu\u00edmica. La supervivencia libre de enfermedad se analiz\u00f3 mediante el m\u00e9todo de kaplan -meyer y su relaci\u00f3n con otras variables mediante el test exacto de breslow. Para el an\u00e1lisis multivariante se utiliz\u00f3 el modelo de regresi\u00f3n de cox.  resultados  fueron incluidos<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n inmunohistoqu\u00edmica del c\u00e1ncer de pr\u00f3stata localizado. valor predictivo de pron\u00f3stico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n inmunohistoqu\u00edmica del c\u00e1ncer de pr\u00f3stata localizado. valor predictivo de pron\u00f3stico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Carlos Tamayo Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel S\u00e1nchez Chapado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Noguerales fraguas <\/li>\n<li>alfredo Rodr\u00edguez antol\u00edn (vocal)<\/li>\n<li>Antonio Ruiz villaespesa (vocal)<\/li>\n<li>Manuel Pamplona casamayor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Carlos Tamayo Ruiz Introduccion el c\u00e1ncer de pr\u00f3stata se ha convertido en los \u00faltimos a\u00f1os en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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