{"id":70277,"date":"2018-03-09T23:14:48","date_gmt":"2018-03-09T23:14:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-una-vacuna-acelular-frente-a-salmonella-enteritidis-evaluacion-de-nuevos-adyuvantes-particulados\/"},"modified":"2018-03-09T23:14:48","modified_gmt":"2018-03-09T23:14:48","slug":"desarrollo-de-una-vacuna-acelular-frente-a-salmonella-enteritidis-evaluacion-de-nuevos-adyuvantes-particulados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/desarrollo-de-una-vacuna-acelular-frente-a-salmonella-enteritidis-evaluacion-de-nuevos-adyuvantes-particulados\/","title":{"rendered":"Desarrollo de una vacuna acelular frente a salmonella enteritidis. evaluaci\u00f3n de nuevos adyuvantes particulados"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Ochoa Rep\u00e1raz <\/strong><\/h2>\n<p>La salmonelosis est\u00e1 considerada como la zoonosis m\u00e1s importante, constituyendo actualmente una pandemia de distribuci\u00f3n mundial. La serovariedad salmonella enteritidis es la m\u00e1s frecuente, y su principal reservorio son las aves de corral y los productos derivados de ellos. Actualmente, como control se emplea vacunas vivas atenuadas y bacterinas. Sin embargo, su eficacia es parcial y presentan diversos problemas asociados que complican su utilizaci\u00f3n, como la virulencia residual, o interferencia con el diagn\u00f3stico serol\u00f3gico.  nuestro trabajo se basa en el empleo vacunal de fracciones subcelulares in\u00f3culas de s.Enteritidis. Tras un estudio antig\u00e9nico preliminar frente a sueros de gallinas infectadas, seleccionamos un extracto enriquecido en: lps, fimbriae, prote\u00ednas de membrana externa (como ompa y porinas), y flagelina. Dicho extracto, denominado he, se obtuvo mediante la aplicaci\u00f3n de vapor fluente sobre c\u00e9lulas de s.Enteritidis resuspendidas en soluci\u00f3n salina. La inmunizaci\u00f3n en rat\u00f3n con el extracto he de una cepa lisa (wt) y de uno de sus mutantes rugosos (r1) indujo una fuerte respuesta protectora (th1 mayor th2).  dichos extractos fueron encapsulados en sistemas particulados de liberaci\u00f3n sostenida conformados por pol\u00edmeros biodegradables. As\u00ed, la encapsulaci\u00f3n del extracto he-wt en nanopart\u00edculas del pol\u00edmero pvm\/ma (gantrez(r)), indujo una inmunidad protectora frente a la infecci\u00f3n letal que perdur\u00f3 en el tiempo (7 semanas), siendo del tipo th2 mayor th1. Por otra parte, el extracto rugoso he-r1 pudro ser eficazmente encapsulado en micropart\u00edculas de poli-*-caprolactona, sin que sus propiedades antig\u00e9nicas variaran. El empleo de esta formulaci\u00f3n en una campa\u00f1a de vacunaci\u00f3n tendr\u00eda la ventaja de no interferir con las pruebas de diagn\u00f3stico serol\u00f3gico basadas en el lps y\/o flagelo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de una vacuna acelular frente a salmonella enteritidis. evaluaci\u00f3n de nuevos adyuvantes particulados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de una vacuna acelular frente a salmonella enteritidis. evaluaci\u00f3n de nuevos adyuvantes particulados <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Ochoa Rep\u00e1raz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Gamazo De La Rasilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Cocheiro nine <\/li>\n<li>bego\u00f1a Sesma vea (vocal)<\/li>\n<li>Mar\u00eda no Domingo \u00e1lvarez (vocal)<\/li>\n<li>xavier Rubies feijoo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Ochoa Rep\u00e1raz La salmonelosis est\u00e1 considerada como la zoonosis m\u00e1s importante, constituyendo actualmente una pandemia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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