{"id":70336,"date":"2018-03-09T23:14:52","date_gmt":"2018-03-09T23:14:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-fisiopatologa%c2%ada-autoinmune-de-la-urticaria-cronica\/"},"modified":"2018-03-09T23:14:52","modified_gmt":"2018-03-09T23:14:52","slug":"estudio-de-la-fisiopatologa%c2%ada-autoinmune-de-la-urticaria-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/estudio-de-la-fisiopatologa%c2%ada-autoinmune-de-la-urticaria-cronica\/","title":{"rendered":"Estudio de la fisiopatolog\u00eda autoinmune de la urticaria cr\u00f3nica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Luquin De Carlos M. Esther <\/strong><\/h2>\n<p>La urticaria cr\u00f3nica es una enfermedad cut\u00e1nea que se caracteriza por la aparici\u00f3n de lesiones eritematohabonosas con prurito generalizado que puede asociarse a angioedema.  la frecuencia de dichos habones suele ser diaria o al menos de dos episodios\/semana, los s\u00edntomas deben persistir durante al menos 6 semanas para que pueda considerarse como urticaria cr\u00f3nica. En el 80% de los casos de urticaria cr\u00f3nica se desconoce la causa, denomin\u00e1ndose idiop\u00e1tica.  se cree que en un 35-40% de los pacientes con urticaria cr\u00f3nica idiop\u00e1tica la enfermedad tiene un origen autoinmune, debida a la presencia de un anticuerpo igg dirigido contra el receptor de ige o bien contra la ige que provoca la activaci\u00f3n de mastocitos y bas\u00f3filos.  con esta tesis se ha querido profundizar por una parte en la hip\u00f3tesis de autoinmundad y en el comportamiento de los bas\u00f3filos de pacientes con urticaria cr\u00f3nica, y por otra parte en el perfiel inmunol\u00f3gico de dicha enfermedad.  estudiamos en primer lugar la capacidad de los sueros de urticaria para activar a bas\u00f3filos de controles sanos, encontrando que el 42% de los sueros de pacientes con urticaria cr\u00f3nica contienen activadores de bas\u00f3filos y de mastocitos que provocan la liberaci\u00f3n de histamina, leucotrienos as\u00ed como de il4.  tambi\u00e9n se estudi\u00f3 el efecto que tiene la il3 en la liberaci\u00f3n de histamina producida por los bas\u00f3filos de pacientes con urticaria cr\u00f3nica tras la activaci\u00f3n con sueros, observando que incrementa la sensibilidad sin disminuir la especificidad. Encontramos niveles de il4 significativamente mayore sen los sueros de pacientes con urticaria frente a los de at\u00f3picos y controles, conteniendo estos dos \u00faltimos grupos niveles similares de dicha citoquina. no se encontraron niveles detectables de ifn-gamma ni de il5 en los sueros. al estimular los linfocitos de pacientes con urticaria cr\u00f3nica y controles con ionomicina y pma, obtuvimos mayor cantidad de linfocitos cd4+ a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la fisiopatolog\u00eda autoinmune de la urticaria cr\u00f3nica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la fisiopatolog\u00eda autoinmune de la urticaria cr\u00f3nica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Luquin De Carlos M. Esther <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marta Ferrer Puga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Bueno <\/li>\n<li>alfonso Sanchez ibarrola (vocal)<\/li>\n<li>Francisco Guerras pasadas (vocal)<\/li>\n<li>Ana Jim\u00e9nez arnau (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luquin De Carlos M. Esther La urticaria cr\u00f3nica es una enfermedad cut\u00e1nea que se caracteriza por la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[13420,153638,1959,153637,153636,123777],"class_list":["post-70336","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-alfonso-sanchez-ibarrola","tag-ana-jimenez-arnau","tag-francisco-guerras-pasadas","tag-jose-bueno","tag-luquin-de-carlos-m-esther","tag-marta-ferrer-puga"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70336","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=70336"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70336\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=70336"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=70336"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=70336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}