{"id":70411,"date":"2018-03-09T23:14:55","date_gmt":"2018-03-09T23:14:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sesquiterpenos-dihidro-beta-agarofuranos-naturales-y-semisinteticos-como-revertidores-del-fenotipo-mdr-mediado-por-p-gp-en-leishmania-tropica\/"},"modified":"2018-03-09T23:14:55","modified_gmt":"2018-03-09T23:14:55","slug":"sesquiterpenos-dihidro-beta-agarofuranos-naturales-y-semisinteticos-como-revertidores-del-fenotipo-mdr-mediado-por-p-gp-en-leishmania-tropica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sesquiterpenos-dihidro-beta-agarofuranos-naturales-y-semisinteticos-como-revertidores-del-fenotipo-mdr-mediado-por-p-gp-en-leishmania-tropica\/","title":{"rendered":"\u00absesquiterpenos dihidro-beta-agarofuranos naturales y semisint\u00e9ticos como revertidores del fenotipo mdr mediado por p-gp en leishmania tropica\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Cort\u00e9s Selva <\/strong><\/h2>\n<p>Con 350 millones de personas en riesgo, 12 millones de afectados y 1.2-2 millones de casos nuevos al a\u00f1o, la leishmaniasis se ha convertido en los \u00faltimos a\u00f1os en la segunda causa de muerte entre las enfermedades parasitarias, despu\u00e9s de la malaria. Entre las razones de este preocupante aumento, encontramos el desarrollo, por parte del par\u00e1sito, de resistencias frente los tratamientos convencionales,  que adem\u00e1s provocan unos efectos secundarios muy severos. actualmente la esperanza est\u00e1 puesta en los alquil-lisofofol\u00edpidos (alp), como la miltefosina, que aunque en un principio fueron desarrollados como antitumorales, se comprob\u00f3 que asimismo poseen actividad antiproliferativa contra leishmania spp., Trypanosoma cruzi y trypanosoma brucei.  las prote\u00ednas tipo glicoprote\u00edna-p (pgp), son bombas activas de membrana que pertenecen a la superfamilia abc (atp-binding-cassette), y est\u00e1n constituidas por dos mitades hom\u00f3logas, cada una de las cuales consta de un dominio transmembrana (tmd), involucrado en la uni\u00f3n y eflujo de los f\u00e1rmacos sustrato, y un dominio citos\u00f3lico de uni\u00f3n a nucle\u00f3tidos (nbd), responsable de la uni\u00f3n e hidr\u00f3lisis del atp, necesaria para el funcionamiento del transportador.  estas prote\u00ednas son responsables del fenotipo de multirresistencia a f\u00e1rmacos (mdr) en organismos procariotas y eucariotas, desde c\u00e9lulas tumorales a protozoos par\u00e1sitos como plasmodium y leishmania.  act\u00faan exportando un amplio espectro de f\u00e1rmacos fuera de la c\u00e9lula, provocando una disminuci\u00f3n de su concentraci\u00f3n intracelular, e impidiendo as\u00ed su acci\u00f3n farmacol\u00f3gica. Es por esta raz\u00f3n por la que existe un gran inter\u00e9s cl\u00ednico en desarrollar inhibidores de estos transportadores, que reviertan el fenotipo mdr y permitan el \u00e9xito de la quimioterapia.  la mayor\u00eda de los revertidores que se conocen interaccionan con los tmds de la pgp, adem\u00e1s suelen ser simult\u00e1neamente sustratos, lo que hace que se requieran con<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00absesquiterpenos dihidro-beta-agarofuranos naturales y semisint\u00e9ticos como revertidores del fenotipo mdr mediado por p-gp en leishmania tropica\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00absesquiterpenos dihidro-beta-agarofuranos naturales y semisint\u00e9ticos como revertidores del fenotipo mdr mediado por p-gp en leishmania tropica\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Cort\u00e9s Selva <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Santiago Castanys Cuello<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: paola Costi Mar\u00eda <\/li>\n<li>mercedes Campillo grau (vocal)<\/li>\n<li> Ruiz p\u00e9rez Luis Miguel (vocal)<\/li>\n<li> Jim\u00e9nez diaz Antonio  ignacio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Cort\u00e9s Selva Con 350 millones de personas en riesgo, 12 millones de afectados y 1.2-2 millones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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