{"id":70465,"date":"2018-03-09T23:14:58","date_gmt":"2018-03-09T23:14:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tecnicas-anala%c2%adticas-para-la-determinacion-de-antipsicoticos-en-sangre\/"},"modified":"2018-03-09T23:14:58","modified_gmt":"2018-03-09T23:14:58","slug":"tecnicas-anala%c2%adticas-para-la-determinacion-de-antipsicoticos-en-sangre","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/tecnicas-anala%c2%adticas-para-la-determinacion-de-antipsicoticos-en-sangre\/","title":{"rendered":"T\u00e9cnicas anal\u00edticas para la determinaci\u00f3n de antipsic\u00f3ticos en sangre."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  S\u00e1nchez De La Torre Hern\u00e1ndez Carolina <\/strong><\/h2>\n<p>El trabajo consiste en la optimizaci\u00f3n y validaci\u00f3n de un m\u00e9todo global para la determinaci\u00f3n anal\u00edtica de los antipsic\u00f3ticos: clorpromazina, levomepromazina, clotiapina, olanzapina, clozapina, haloperidol y tioridazina en muestras de sangre. Las concentraciones del estudio corresponden a los valores terap\u00e9uticos, terap\u00e9uticos altos y t\u00f3xicos. El estudio se aborda optimizando el m\u00e9todo de extracci\u00f3n en fase s\u00f3lida, estudiando distintos procedimientos en diversas columnas de extracci\u00f3n de fundamento diferente. Una vez elegido aquel procedimiento de extracci\u00f3n en fase s\u00f3lida que proporciona mejor rendimiento de extracci\u00f3n y cromatogramas m\u00e1s limpios, se procede a realizar un estudio de validaci\u00f3n comparativo de dicho procedimiento de extracci\u00f3n en fase s\u00f3lida con otro procedimiento de extracci\u00f3n l\u00edquido-l\u00edquido sobre soporte s\u00f3lido. Dichos extractos se analizan por un m\u00e9todo de cromatograf\u00eda de gases con detector de nitr\u00f3geno-f\u00f3sforo (gc-npd). El estudio de validaci\u00f3n abarca par\u00e1metros como selectividad del m\u00e9todo gc-npd, sensibilidad con patrones, exactitud y precisi\u00f3n, l\u00edmites de detecci\u00f3n y cuantificaci\u00f3n, y estimaci\u00f3n de la incertidumbre de determinaci\u00f3n. Se estudia la precisi\u00f3n en condiciones de repetibilidad (serie intra-ensayo)  y de reproducibilidad (serie inter-ensayo).  tras el estudio de validaci\u00f3n comparativo realizado se llega a las siguientes conclusiones finales:  &#8211;       la extracci\u00f3n en fase s\u00f3lida con columnas bond elut certify proporciona extractos m\u00e1s limpios, con mejores rendimientos de extracci\u00f3n, mejor precisi\u00f3n, mayor sensibilidad, menor consumo de disolventes y menor volumen posterior de material de desecho (residuos) que la extracci\u00f3n l\u00edquido-l\u00edquido sobre soporte s\u00f3lido en columnas chem elut.  &#8211;       la cromatograf\u00eda de gases con detector de nitr\u00f3geno-f\u00f3sforo (gc-npd):  o       es una t\u00e9cnica altamente sensible y espec\u00edfica para compuestos con nitr\u00f3geno<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>T\u00e9cnicas anal\u00edticas para la determinaci\u00f3n de antipsic\u00f3ticos en sangre.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 T\u00e9cnicas anal\u00edticas para la determinaci\u00f3n de antipsic\u00f3ticos en sangre. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  S\u00e1nchez De La Torre Hern\u00e1ndez Carolina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Mart\u00ednez Gonz\u00e1lez Mar\u00eda Antonia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benito Del castillo garcia <\/li>\n<li>Manuel Sancho ruiz (vocal)<\/li>\n<li>Francisco Zaragoza garcia (vocal)<\/li>\n<li> Gasc\u00f3 a\u00f1berich M\u00aa pilar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de S\u00e1nchez De La Torre Hern\u00e1ndez Carolina El trabajo consiste en la optimizaci\u00f3n y validaci\u00f3n de un m\u00e9todo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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