{"id":7047,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/toxicidad-de-la-ciclosporina-a-evaluacion-del-efecto-anticolestatico-y-hepatoprotector-de-la-s-adenosil-l-metionina\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"toxicidad-de-la-ciclosporina-a-evaluacion-del-efecto-anticolestatico-y-hepatoprotector-de-la-s-adenosil-l-metionina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/toxicidad-de-la-ciclosporina-a-evaluacion-del-efecto-anticolestatico-y-hepatoprotector-de-la-s-adenosil-l-metionina\/","title":{"rendered":"Toxicidad de la ciclosporina a. evaluacion del efecto anticolestatico y hepatoprotector de la s-adenosil-l-metionina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Emilio Fernandez Dominguez <\/strong><\/h2>\n<p>Este estudio examina, en primer termino, los efectos del tratamiento prolongado con ciclosporina a (cya) sobre la funcion hepatobiliar en la rata. El tratamiento con el farmaco da lugar a la aparicion de un sindrome colestatico que cursa con incrementos de las concentraciones plasmaticas de acidos biliares y de bilirrubina, y con descensos en el flujo de bilis y en la secrecion biliar de acidos biliares, colesterol, fosfolipidos, y-glutamil tranferasa y fosfatasa acida.  tambien se observaron alteraciones en otros indicadores plasmaticos del funcionalismo hepatico, renal y pancreatico. Los efectos de la cya sobre la funcion hepatobiliar estarian mediados por alteraciones a nivel de la membrana plasmatica del hepatocito y\/o del citoesqueleto. En segundo lugar, se estudian los efectos que el cotratamiento con s-adenosil-l-metionina (same) ejerce sobre las alteraciones inducidas por el tratamiento con cya. Los resultados obtenidos indican que la same antagoniza, total o parcialmente, las principales modificaciones inducidas por el tratamiento con cya sobre la funcion hepatobiliar. Asi, se recupera parcialmente el flujo biliar y la secrecion de colesterol, y-glutamil transferasa y fosfatasa acida, y totalmente la secrecion de acidos biliares y fosfolipidos. Asimismo, la hiperbilirrubinemia inducida por la cya es totalmente revertida, mejorando tambien la concentracion plasmatica de acidos biliares y la hipoproteinemia inducida por el inmunosupresor. Estos efectos de la same estarian relacionados con su participacion en reacciones hepaticas de transulfuracion y\/o transmetilacion.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Toxicidad de la ciclosporina a. evaluacion del efecto anticolestatico y hepatoprotector de la s-adenosil-l-metionina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Toxicidad de la ciclosporina a. evaluacion del efecto anticolestatico y hepatoprotector de la s-adenosil-l-metionina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Emilio Fernandez Dominguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Jimenez Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Mato De La Paz <\/li>\n<li>Margarita Sanchez Campos (vocal)<\/li>\n<li>Alfonso Jes\u00fas Dominguez Gil Hurle (vocal)<\/li>\n<li>Pablo Ortiz Betes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Emilio Fernandez Dominguez Este estudio examina, en primer termino, los efectos del tratamiento prolongado con ciclosporina a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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