{"id":70482,"date":"2018-03-09T23:14:58","date_gmt":"2018-03-09T23:14:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regenario-de-la-poblacio-cel-lular-beta-dels-illots-pancrea-tics-indua%c2%afda-per-tungstat\/"},"modified":"2018-03-09T23:14:58","modified_gmt":"2018-03-09T23:14:58","slug":"regenario-de-la-poblacio-cel-lular-beta-dels-illots-pancrea-tics-indua%c2%afda-per-tungstat","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/regenario-de-la-poblacio-cel-lular-beta-dels-illots-pancrea-tics-indua%c2%afda-per-tungstat\/","title":{"rendered":"Regenari\u00f3 de la poblaci\u00f3 cel-lular beta dels illots pancre\u00c1\u00a0tics indu\u00c1\u00afda per tungstat."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bel\u00e9n Nadal Mart\u00edn <\/strong><\/h2>\n<p>La diabetes mellitus se desarrolla como consecuencia de la destruci\u00f3n de la masa culular b pancre\u00e1tica, en el caso de la diabetes tipo 1, o bien por la imposibilidad de compensaci\u00f3n ante la demanda de insulina, por parte de la c\u00e9lula b, as\u00ed como una resistencia a la hormona por los tejidos perif\u00e9ricos, en las diabetes tipo 2.La importancia de la masa celular b, por tanto , hace que las investigaciones sobre nuevas tarapias se centran en la obtenci\u00f3n de c\u00e9lulas b,plenamente funcionales, que permtan un \u00f3ptimo control de la homeostasis de la glucosa.La administraci\u00f3n de tungstato s\u00f3dico se enmarca dentro de la experimentaci\u00f3n con metal-iones como potentes agentes antidiab\u00e9ticos en diversos modelos animales de diabetes.En esta tesis , se describe el efecto del tratamiento oral con tengstato a animales diab\u00e9ticos sobre la masa celular b pancre\u00e1tica.  la nomalizaci\u00f3n de la glicemia observada tras la administraci\u00f3n oral de tungstato a ratas diab\u00e9ticas(modelo nstz) es consecuencia de una regeneraci\u00f3n total de la poblaci\u00f3n celuclar b.Los estudios demuestran que esta regeneraci\u00f3n es debida a la activaci\u00f3n del proceso de neog\u00e9nesis (formaci\u00f3n de c\u00e9lulas de novo), con la implicaci\u00f3n del factor de transcripci\u00f3n pdx-1.La activaci\u00f3n de este factor, adem\u00e1s es probablemente la responsable del aumento observado en la bios\u00edntesis de insulina en los animales diab\u00e9ticos tratados con tungstato.Un aspecto importante de este estudio es que la nueva poblaci\u00f3n b, semantiene estable tras el cese de la administraci\u00f3n del compuesto, permitiendo mantenerse a los animales en un estado normoglic\u00e9mico durante el per\u00edodo de tiempo estudiado.  en el modelo animal stz, con una acusada carencia de masa celular b, la administraci\u00f3n de tungstato diminuye la hiperglicemia y provoca un ligero aumento de la poblaci\u00f3n celular b.Sin embargo , en animales a los que se les administrado una dosis exog\u00e9na de insulina, mediante transplante de islot<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regenari\u00f3 de la poblaci\u00f3 cel-lular beta dels illots pancre\u00c1\u00a0tics indu\u00c1\u00afda per tungstat.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regenari\u00f3 de la poblaci\u00f3 cel-lular beta dels illots pancre\u00c1\u00a0tics indu\u00c1\u00afda per tungstat. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bel\u00e9n Nadal Mart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ramon Gomis De Barbar?<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joana Mar\u00eda Planas rossell\u00f3 <\/li>\n<li>josep Mar\u00eda Fernandez novell (vocal)<\/li>\n<li>anna Novials sard? (vocal)<\/li>\n<li>reyes Jorge dom\u00ednguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bel\u00e9n Nadal Mart\u00edn La diabetes mellitus se desarrolla como consecuencia de la destruci\u00f3n de la masa culular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,115,350,851,258],"tags":[153895,153893,19731,153894,1375,153896],"class_list":["post-70482","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-bioquimica-molecular","category-embriologia","category-endocrinologia","category-hormonas","tag-anna-novials-sard","tag-belen-nadal-martin","tag-joana-maria-planas-rossello","tag-josep-maria-fernandez-novell","tag-ramon-gomis-de-barbar","tag-reyes-jorge-dominguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=70482"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70482\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=70482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=70482"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=70482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}