{"id":70498,"date":"2018-03-09T23:15:02","date_gmt":"2018-03-09T23:15:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/localizacion-de-las-regiones-de-interaccion-con-rna-de-las-proteinas-del-virus-respiratorio-sincitial-humano-vrsh-n-y-m2-1\/"},"modified":"2018-03-09T23:15:02","modified_gmt":"2018-03-09T23:15:02","slug":"localizacion-de-las-regiones-de-interaccion-con-rna-de-las-proteinas-del-virus-respiratorio-sincitial-humano-vrsh-n-y-m2-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/localizacion-de-las-regiones-de-interaccion-con-rna-de-las-proteinas-del-virus-respiratorio-sincitial-humano-vrsh-n-y-m2-1\/","title":{"rendered":"Localizaci\u00f3n de las regiones de interacci\u00f3n con rna de las proteinas del virus respiratorio sincitial humano vrsh n y m2-1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isabel Cuesta De La Plaza <\/strong><\/h2>\n<p>El virus respiratorio sincital humano (vrsh) es un pneumovirus de la familia paramyxoviridae, que causa infecciones graves en el tracto respiratorio inferior en ni\u00f1\u00f3s peque\u00f1os , personas inmunodeprimidas o con afecciones cardiovasculares y ancianos. Hechos tales como la variabilidad antig\u00e9nica del virus, que afecte a poblaciones tan diferentes y la incapacidad de la primoinfecci\u00f3n para desarrollar una respuesta inmune protectora y duradera , sugieren que las estrategias m\u00e1s adecuadas a seguir para le control sanitario de la infecci\u00f3n es desarrollar compuestos antivirales y generar mediante gen\u00e9tica reversa virus vivos atenuados vacunales.  las ribonucleoprote\u00ednas son componentes internos de las prat\u00edculas virales y las unidads funcionales para los procesos de transcripci\u00f3n y replicaci\u00f3n viral. Est\u00e1n compuestas por el rna viral, de polaridad negativa no segmentado, fuertemente unido a la prote\u00edna n constituyendo la nucleoc\u00e1psida viral, a esta se le une la rna polimerasa viral, prote\u00edna l, y sus cofactores las fosfoprote\u00ednas p y m2-1 . Las prote\u00ednas de las rnpa son multifuincionales y est\u00e1n implicadas en funciones espec\u00edficas virales, lo que las convierte en dianas id\u00f3neas para la acci\u00f3n de compuestos antivirales y portadores de mutaciones que confeir\u00edan atenuaci\u00f3n a virus vivos. Con el fin de entender como desempe\u00f1an dichas prote\u00ednas sus funciones durante el ciclo de crecimiento del virus a nivel molecular, etudiamos algunas de las interaciones que establecen con diferentes componentes virales.  demostramos que la prote\u00edna m2-1 une rna, con una cin\u00e9tica cooperativa y reconoce la secuencia del crna leader en el contexto de un rna de 86nt. la regi\u00f3n de uni\u00f3n a rna se localiz\u00f3 entre los residuos 33-37,43-48 y 59-62 de la prote\u00edna . Se determin\u00f3 que la t59 y s58 sonlos residuos que se fosforilan y que dicha modificaci\u00f3n disminuye su uni\u00f3n a rna. La interaci\u00f3n de la prote\u00edna m2-1 con el rna a trav\u00e9s de los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Localizaci\u00f3n de las regiones de interacci\u00f3n con rna de las proteinas del virus respiratorio sincitial humano vrsh n y m2-1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Localizaci\u00f3n de las regiones de interacci\u00f3n con rna de las proteinas del virus respiratorio sincitial humano vrsh n y m2-1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isabel Cuesta De La Plaza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Nieves Villanueva Vico<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: julian Perera gonzalez <\/li>\n<li>Juan Ortin monton (vocal)<\/li>\n<li>Rafael Fern\u00e1ndez mu\u00f1oz (vocal)<\/li>\n<li> Almendral del r\u00edo Jos\u00e9 m. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isabel Cuesta De La Plaza El virus respiratorio sincital humano (vrsh) es un pneumovirus de la familia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[7261,153925,14725,7259,63076,38633],"class_list":["post-70498","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-almendral-del-rio-jose-m","tag-isabel-cuesta-de-la-plaza","tag-juan-ortin-monton","tag-julian-perera-gonzalez","tag-nieves-villanueva-vico","tag-rafael-fernandez-munoz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70498","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=70498"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70498\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=70498"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=70498"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=70498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}