{"id":70499,"date":"2018-03-09T23:15:02","date_gmt":"2018-03-09T23:15:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-perfiles-de-expresion-de-las-citocinas-en-las-reacciones-adversas-a-farmacos\/"},"modified":"2018-03-09T23:15:02","modified_gmt":"2018-03-09T23:15:02","slug":"estudio-de-los-perfiles-de-expresion-de-las-citocinas-en-las-reacciones-adversas-a-farmacos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/estudio-de-los-perfiles-de-expresion-de-las-citocinas-en-las-reacciones-adversas-a-farmacos\/","title":{"rendered":"Estudio de los perfiles de expresi\u00f3n de las citocinas en las reacciones adversas a farmacos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Posadas Ma\u00f1anes Sinforiano Jose <\/strong><\/h2>\n<p>Este trabajo explora mediadores esenciales en la respuesta inmunol\u00f3gica como son las citocinas en la monitorizaci\u00f3n de las reacciones de al\u00e9rgicas a medicamentos. Se trata de un estudio descriptivo donde se analiza la expresi\u00f3n del gen y la prote\u00edna de un grupo de estos mediadores inmunol\u00f3gicos mediante distintas t\u00e9cnicas de bioqu\u00edmicas y de biolog\u00eda molecular como son la reacci\u00f3n en cadena de la polimerasa (pcr), pcr competitiva, pcr en tiempo real y enzimo-inmunoensayo. Los grupos de individuos (pacientes y controles) incluidos en el trabajo fueron validados en la diagnosis de las distintas entendidas cl\u00ednicas agrupadas como reacciones inmediatas a medicamentos y reacciones no-inmediatas a los mismos. Los controles fueron individuos sanos; y expuestos a los mismos medicamentos que provocaron las reacciones al\u00e9rgicas en los pacientes. Se pudieron establecer distintas asociaciones entre citocinas, entre las determinaciones realizadas por diferentes t\u00e9cnicas. La conclusi\u00f3n principal de la tesis es que las reacciones al\u00e9rgicas a medicamentos siguen el paradigma th1\/th2 correspondiendo el primer perfil de citocinas a las reacciones no-inmediatas y el segundo a las reacciones inmediatas a medicamentos. Tambi\u00e9n se pudo confirmar dicha conclusi\u00f3n cuando se analizaron los factores de transcripci\u00f3n que intervienen en el control de la s\u00edntesis de las citocinas analizadas. Por \u00faltimo tambi\u00e9n se pudo demostrar que los mediadores que intervienen en la apoptosis celular como la perforina, granzima b yfas-l participan en los mecanismos efectores de las c\u00e9lulas del sistema inmunol\u00f3gico en las reacciones no-inmediatas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los perfiles de expresi\u00f3n de las citocinas en las reacciones adversas a farmacos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los perfiles de expresi\u00f3n de las citocinas en las reacciones adversas a farmacos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Posadas Ma\u00f1anes Sinforiano Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Juarez Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eugenio Jimenez gutierrez <\/li>\n<li>joaquim Mullol miret (vocal)<\/li>\n<li>Jos\u00e9 Miguel Carballo villarino (vocal)<\/li>\n<li>Mar\u00eda Jos\u00e9 Torres ja\u00e9n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Posadas Ma\u00f1anes Sinforiano Jose Este trabajo explora mediadores esenciales en la respuesta inmunol\u00f3gica como son las citocinas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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