{"id":70536,"date":"2018-03-09T23:15:02","date_gmt":"2018-03-09T23:15:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-protector-de-fraxetol-y-miricetina-frente-a-la-neurotoxicidad-inducida-por-rotenona-en-celulas-de-neuroblastoma\/"},"modified":"2018-03-09T23:15:02","modified_gmt":"2018-03-09T23:15:02","slug":"efecto-protector-de-fraxetol-y-miricetina-frente-a-la-neurotoxicidad-inducida-por-rotenona-en-celulas-de-neuroblastoma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-protector-de-fraxetol-y-miricetina-frente-a-la-neurotoxicidad-inducida-por-rotenona-en-celulas-de-neuroblastoma\/","title":{"rendered":"Efecto protector de fraxetol y miricetina frente a la neurotoxicidad inducida por rotenona en c\u00e9lulas de neuroblastoma"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Molina Jimenez M. Francisca <\/strong><\/h2>\n<p>En los \u00faltimos a\u00f1os, las enfermedades neurodegenerativas, entre ellas la enfermedad de parkinson, han cobrado gran relevancia debido al aumento de la esperanza de vida en los pa\u00edses desarrollados. Las causas y mecanismos por lo que se produce la degeneraci\u00f3n neuronal de las sustancia negra de enfermos de parkinson es aun desconocida, aunque en este estudio se pone de manifiesto la implicaci\u00f3n del estr\u00e9s oxidativo y de los mecanismos de apoptosis.  los objetivos de este trabajo fueron caracterizar un modelo in vitro que permita establecer la relaci\u00f3n entre la enfermedad de parkinson, el estr\u00e9s oxidativo y la muerte neuronal por apoptosis. Se emple\u00f3 rotenona, inhibidor del complejo i de la cadena de transporte electr\u00f3nico mitocondrial, para inducir la toxicidad y se comprob\u00f3 la capacidad neuroprotectora de tres sustancias antioxidantes: fraxetrol, miricetina y n-acetilciste\u00edna. La rotenona provoc\u00f3 estr\u00e9s oxidativo en las c\u00e9lula sdopamin\u00e9rgicas de neuroblastoma humana sh-sy5y, incrementando la producci\u00f3n de ero, ocasionando peroxidaci\u00f3n lip\u00eddica, disminuyendo los niveles de gsh, y alterando la actividad y los niveles de la sprincipales enzimas antioxidantes. Todas estas alteraciones del estado redox celular condujeron a la muerte neuronal por apoptosis en c\u00e9lulas dopamin\u00e9rgicas de neuroblastoma humano sh-sy5y que se comprob\u00f3 por cambios morfol\u00f3gicos caracter\u00edsticos, activaci\u00f3n de caspasa 3, proteolisis de poli-adpribosa polimerasa (parp) y fragmentaci\u00f3n internucleosomal de dna. El fraxetol fuez capaz de revertir esta situaci\u00f3n de toxicidad frenando el estr\u00e9s oxidativo gracias a su capacidad captadora de ero, evitando la apoptosis por inhibir la proteolisis de parp y la fragmentaci\u00f3n de dna, e incrementando las defensas celulares por inducir la expresi\u00f3n g\u00e9nica de hsp70. Adem\u00e1s inhibi\u00f3 la cox-2, mediadora en el proceso de inflamaci\u00f3n implicado en la muerte neuronal de gsh y la actividad de gpx inhibiendo tamb<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto protector de fraxetol y miricetina frente a la neurotoxicidad inducida por rotenona en c\u00e9lulas de neuroblastoma<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto protector de fraxetol y miricetina frente a la neurotoxicidad inducida por rotenona en c\u00e9lulas de neuroblastoma <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Molina Jimenez M. Francisca <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan a Benedi Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: evangelina Palacios alaiz <\/li>\n<li>valent\u00edn Cena callejo (vocal)<\/li>\n<li>Francisco Zaragoza garcia (vocal)<\/li>\n<li>Mar\u00eda Cascales angosto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Molina Jimenez M. Francisca En los \u00faltimos a\u00f1os, las enfermedades neurodegenerativas, entre ellas la enfermedad de parkinson, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[5948,4080,70877,4825,153990,7038],"class_list":["post-70536","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-evangelina-palacios-alaiz","tag-francisco-zaragoza-garcia","tag-juan-a-benedi-gonzalez","tag-maria-cascales-angosto","tag-molina-jimenez-m-francisca","tag-valentin-cena-callejo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70536","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=70536"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70536\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=70536"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=70536"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=70536"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}