{"id":70561,"date":"2018-03-09T23:15:06","date_gmt":"2018-03-09T23:15:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificacion-del-flujo-sangua%c2%adneo-carota%c2%addeo-y-cerebral-mediante-estimulacion-electrica-de-la-medula-espinal-cervical-estudio-preliminar-del-potencial-radiosensibilizante\/"},"modified":"2018-03-09T23:15:06","modified_gmt":"2018-03-09T23:15:06","slug":"modificacion-del-flujo-sangua%c2%adneo-carota%c2%addeo-y-cerebral-mediante-estimulacion-electrica-de-la-medula-espinal-cervical-estudio-preliminar-del-potencial-radiosensibilizante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificacion-del-flujo-sangua%c2%adneo-carota%c2%addeo-y-cerebral-mediante-estimulacion-electrica-de-la-medula-espinal-cervical-estudio-preliminar-del-potencial-radiosensibilizante\/","title":{"rendered":"Modificaci\u00f3n del flujo sangu\u00edneo carot\u00eddeo y cerebral mediante estimulaci\u00f3n el\u00e9ctrica de la m\u00e9dula espinal cervical. estudio preliminar del potencial radiosensibilizante."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bernardino Clavo Varas <\/strong><\/h2>\n<p>Introducci\u00f3n:  la hipoxia-isquemia es frecuente en los tumores, siendo un importante factor pron\u00f3stico adverso. Limita la llegada de quimioterapia y ox\u00edgeno al tumor, siendo las c\u00e9lulas hip\u00f3xicas hasta 3 veces m\u00e1s resistentes a radioterapia. adem\u00e1s, la isquemia-hipoxia selecciona clones tumorales m\u00e1s agresivos y con apoptosis disminuida, lo que produce resistencia adicional a radioterapia y quimioterapia. La estimulaci\u00f3n el\u00e9ctrica de la m\u00e9dula espinal (eme) es una t\u00e9cnica neuroquir\u00fargica m\u00ednimamente invasiva, entre cuyas indicaciones est\u00e1 el tratamiento s\u00edndromes de isquemia perif\u00e9rica y cardiaca.  esta tesis es resultado de un estudio prospectivo cuyo objetivo consisti\u00f3 en evaluar algo que no hab\u00eda sido estudiado previamente: si la eme pod\u00eda modificar el flujo sangu\u00edneo local y regional, y con ello la isquemia-hipoxia, en tumores cerebrales.  material y m\u00e9todos:  se estudiaron 18 pacientes con tumores cerebrales de alto grado de malignidad, a quienes se les implanto un dispositivo de eme. Sin y con eme, y antes del tratamiento previsto con radio-quimioterapia, se realizaron los siguientes estudios:  1) spect (single photon emission computed tomography) para evaluar el flujo cerebral en el tejido tumoral y sano.  2) doppler transcraneal, para evaluar la velocidad (cm\/s) del flujo sist\u00f3lico y diast\u00f3lica en la arterial cerebral media.  3) doppler color, para evaluar el flujo sangu\u00edneo (ml\/min) en arteria car\u00f3tida com\u00fan.  4) electrodos polarogr\u00e1ficos, para determinaci\u00f3n directa \u00abin vivo\u00bb de la oxigenaci\u00f3n (mmhg) en tejido tumoral y sano.  5) pet (tomograf\u00eda de emisi\u00f3n de positrones), para evaluar el metabolismo de la glucosa en tejido tumoral y sano.  resultados y discusi\u00f3n:  1) en situaci\u00f3n basal, sin eme, el flujo sangu\u00edneo y la oxigenaci\u00f3n tumoral fueron menores que en tejido sano, confirmando los datos y experiencias en radiobiolog\u00eda.  2) el flujo sangu\u00edneo en la arteria cerebral medi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaci\u00f3n del flujo sangu\u00edneo carot\u00eddeo y cerebral mediante estimulaci\u00f3n el\u00e9ctrica de la m\u00e9dula espinal cervical. estudio preliminar del potencial radiosensibilizante.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaci\u00f3n del flujo sangu\u00edneo carot\u00eddeo y cerebral mediante estimulaci\u00f3n el\u00e9ctrica de la m\u00e9dula espinal cervical. estudio preliminar del potencial radiosensibilizante. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bernardino Clavo Varas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/09\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Robaina Padr\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Carreras delgado <\/li>\n<li>benilde Ram\u00f3n valc\u00e1rcel (vocal)<\/li>\n<li> Calvo Manuel felipe \u00e1ngel (vocal)<\/li>\n<li>Santiago Oya otero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bernardino Clavo Varas Introducci\u00f3n: la hipoxia-isquemia es frecuente en los tumores, siendo un importante factor pron\u00f3stico adverso. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[31051,154038,61588,154039,1812,36168],"class_list":["post-70561","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-benilde-ramon-valcarcel","tag-bernardino-clavo-varas","tag-calvo-manuel-felipe-angel","tag-francisco-robaina-padron","tag-jose-luis-carreras-delgado","tag-santiago-oya-otero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=70561"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70561\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=70561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=70561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=70561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}