{"id":70629,"date":"2004-01-10T00:00:00","date_gmt":"2004-01-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-entre-factores-geneticos-y-toxinas-ambientales-en-una-linea-de-raton-transgenico-que-sobreexpresa-alfa-sinucleina-humana-mutada-como-modelo-de-enfermedad-con-cuerpos-de-lewy\/"},"modified":"2004-01-10T00:00:00","modified_gmt":"2004-01-10T00:00:00","slug":"interaccion-entre-factores-geneticos-y-toxinas-ambientales-en-una-linea-de-raton-transgenico-que-sobreexpresa-alfa-sinucleina-humana-mutada-como-modelo-de-enfermedad-con-cuerpos-de-lewy","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neurologia\/interaccion-entre-factores-geneticos-y-toxinas-ambientales-en-una-linea-de-raton-transgenico-que-sobreexpresa-alfa-sinucleina-humana-mutada-como-modelo-de-enfermedad-con-cuerpos-de-lewy\/","title":{"rendered":"Interaccion entre factores geneticos y toxinas ambientales en una linea de raton transgenico que sobreexpresa alfa sinucleina humana mutada como modelo de enfermedad con cuerpos de lewy"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Nieto Bodelon <\/strong><\/h2>\n<p>En adici\u00f3n al componente gen\u00e9tico, los factores ambientales tambi\u00e9n han sido considerados como contribuyentes potenciales en la patog\u00e9nesis de la ep. En el siguiente trabajo hemos pretendido estudiar de cerca la interacci\u00f3n entre dichos factores en una linea transg\u00e9nica que sobreexpresa alfa sinucleina humana con la mutaci\u00f3n a30p, mediante el an\u00e1lisis del nivel de sensibilidad de este modelo a  la exposici\u00f3n a neurotoxinas como el l-metil-4-fenil-l,2,3,6-tetrahidropiridinio (mptp) o la rotenona. Mientras que el incremento de la vulnerabilidad al tratamiento con retenona no fue evidente en la l\u00ednea tg5093, la exposici\u00f3n cr\u00f3nica a dosis de 80 mg\/kg y 150 mg\/kg de mptp provoco un deterioro acusado en el sistema nigroestriatal dopamin\u00e9rgico. Un efecto determinado mediante la cuantificaci\u00f3n de las neuronas inmunorreactivas para tirosina hidroxilasa (th) en la sustancia negra, la cuantificaci\u00f3n de los niveles de th estriatal, y la cuantificaci\u00f3n de los niveles de dopamina (da) en el estriado de los ratones tg5093, en comparaci\u00f3n a sus correspondientes ratones no transg\u00e9nicos. Por lo tanto, la interacci\u00f3n entre la sobreexpresi\u00f3n de alfa si nucle\u00edna humana a30p y el tratamiento con mptp promovi\u00f3 la aparici\u00f3n de un fenotipo degenerativo dependiente de la disfunci\u00f3n dopamin\u00e9rgica en la l\u00ednea tg5093, surgiendo un efecto delet\u00e9reo de la alfa si nucle\u00edna mutada en la vulnerabilidad y supervivencia de las neuronas dopamin\u00e9rgicas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interaccion entre factores geneticos y toxinas ambientales en una linea de raton transgenico que sobreexpresa alfa sinucleina humana mutada como modelo de enfermedad con cuerpos de lewy<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interaccion entre factores geneticos y toxinas ambientales en una linea de raton transgenico que sobreexpresa alfa sinucleina humana mutada como modelo de enfermedad con cuerpos de lewy <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Nieto Bodelon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Teresa Gomez Isla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: isidre Ferrer ibizanda <\/li>\n<li>M\u00aa rosario Luquin piudo (vocal)<\/li>\n<li>jordi Perez tur (vocal)<\/li>\n<li>Juan  Francisco Medina cabrera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Nieto Bodelon En adici\u00f3n al componente gen\u00e9tico, los factores ambientales tambi\u00e9n han sido considerados como contribuyentes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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