{"id":70675,"date":"2004-06-10T00:00:00","date_gmt":"2004-06-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-mediante-el-estudio-de-genes-asociados-a-la-virulencia-de-aislamientos-cla%c2%adnicos-de-helicobacter-pylori\/"},"modified":"2004-06-10T00:00:00","modified_gmt":"2004-06-10T00:00:00","slug":"caracterizacion-mediante-el-estudio-de-genes-asociados-a-la-virulencia-de-aislamientos-cla%c2%adnicos-de-helicobacter-pylori","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-mediante-el-estudio-de-genes-asociados-a-la-virulencia-de-aislamientos-cla%c2%adnicos-de-helicobacter-pylori\/","title":{"rendered":"Caracterizaci\u00f3n mediante el estudio de genes asociados a la virulencia de aislamientos cl\u00ednicos de helicobacter pylori"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Angel Garcia Campos <\/strong><\/h2>\n<p>Uno de los principales interrogantes por responder sobre la infecci\u00f3n por helicobacter pylori es conocer por qu\u00e9 s\u00f3lo ello-20 % de las personas infectadas por esta bacteria desarrollan enfermedades g\u00e1stricas y el resto s\u00f3lo desarrolla gastritis. De ah\u00ed la importancia de caracterizar aislamientos cl\u00ednicos de pacientes sufriendo distintas patolog\u00edas, con factores asociados a la virulencia. En esta tesis hemos querido caracterizar aislamientos cl\u00ednicos de h. Pylori procedentes de pacientes adultos o ni\u00f1os con \u00falcera o gastritis, estudiando la presencia o ausencia de genes cl\u00e1sicos asociados a virulencia (caga, vaca y hpaa); poner a punto las t\u00e9cnicas correctas para el estudio de  nuevos genes que est\u00e1n siendo asociados a virulencia (hopq, baba2) o de nuevos  factores asociados a virulencia que actualmente no se conoce con exactitud qu\u00e9 genes lo codifican (ant\u00edgenos de lewis). Tambi\u00e9nhemos querido conocer la sensibilidad antimicrobianade estos aislamientos por t\u00e9cnicas fenot\u00edpicas y comprobar la utilidad de t\u00e9cnicas moleculares para el estudio de la resistencia a claritromicina.Buscamos la relaci\u00f3n existente entre todos estos factores. las cepas de adultos son positivas m\u00e1s frecuentemente para los genes caga, hopq y hpaa. As\u00ed como en pacientes que padecen de \u00falcera es m\u00e1s frecuente encontrar cepas caga+, vacas], hopq, hpaa y sensiblesa  claritromicina.En los ni\u00f1os son m\u00e1s ffecuentes las cepas hopq, hpaa y vacas2.  cuando se agruparon las cepas teniendo en cuenta todos los factores estudiados  aparecieron diferencias entre los patrones originados de las cepas de pacientes con gastritis y \u00falcera, fundamentalmenteen la expresi\u00f3n del gen baba2 y la distinta sensibilidada claritromicinay metronidazol en este estudiono obtuvimosrelaci\u00f3nentrela patolog\u00eday la expresi\u00f3nde los ant\u00edgenos  de lewis estudiados. La realizaci\u00f3nde un elisa es el m\u00e9todo m\u00e1s sensiblede los  comparados para la detecci\u00f3n de la expresi\u00f3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n mediante el estudio de genes asociados a la virulencia de aislamientos cl\u00ednicos de helicobacter pylori<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n mediante el estudio de genes asociados a la virulencia de aislamientos cl\u00ednicos de helicobacter pylori <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Angel Garcia Campos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>brea Calvo L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Prieto prieto <\/li>\n<li> Sanz moreno Juan  Carlos (vocal)<\/li>\n<li>teresa Alarc\u00f3n cavero (vocal)<\/li>\n<li> Martinez gomez Mar\u00eda  josefa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Angel Garcia Campos Uno de los principales interrogantes por responder sobre la infecci\u00f3n por helicobacter pylori [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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