{"id":70714,"date":"2004-08-10T00:00:00","date_gmt":"2004-08-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-del-melanoma-metastasico-pulmonar-modelo-esperimental\/"},"modified":"2004-08-10T00:00:00","modified_gmt":"2004-08-10T00:00:00","slug":"tratamiento-del-melanoma-metastasico-pulmonar-modelo-esperimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tratamiento-del-melanoma-metastasico-pulmonar-modelo-esperimental\/","title":{"rendered":"Tratamiento del melanoma metastasico pulmonar, modelo esperimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Martinez Conesa <\/strong><\/h2>\n<p>Resumen  realizamos el estudio de los efectos de seis compuestos fen\u00f3licos y el vino tinto sobre el melanoma metast\u00e1sico pulmonar compar\u00e1ndolos con la interfer\u00f3n. Los agentes se suministraron en la comida y en la bebida durante 11 d\u00edas previos a la inoculaci\u00f3n de las c\u00e9lulas tumorales y durante los 21 d\u00edas siguientes. Los agentes ensayados fueron administrados tanto en la comida como en la bebida \u00abad libitum\u00bb. Los flavonoides fuer\u00f3n disueltos (0,2%peso\/volumen) en agua\/etanol al 98,8:1,2 volumen:volumen, excepto el gsps que fu\u00e9 disuelto directamente en agua. El vino tinto h\u00e9cula fue reducido a 91,2 agua:8,8 vino v\/v. El interfer\u00f3n alfa y el pbs, se administraron en la regi\u00f3n inguinal izquierda\/s.C. (Lunes, mi\u00e9rcoles y viernes): 12.500, 25.000, 50.00 y 100.000 ui\/ rat\u00f3n, con unas dosis totales de 150.000, 300.000, 600.000 y 1.200.000 ui\/rat\u00f3n.  la implantaci\u00f3n de 5&#215;105 c\u00e9lulas b16f10 se realiz\u00f3 mediante inoculaci\u00f3n en la vena lateral de la cola a 162 ratones swiss. Realizamos la valoraci\u00f3n cuantitativa de los n\u00f3dulos metast\u00e1sicos seg\u00fan: a) un modelo macrosc\u00f3pico contando los n\u00f3dulos metast\u00e1sicos de la superficie pleural de los cinco l\u00f3bulos y b) modelo microsc\u00f3pico, mediante el an\u00e1lisis cuantitativo sobre 5 secciones histol\u00f3gicas de cada uno de los l\u00f3bulos pulmonares: calculamos el \u00e1rea del l\u00f3bulo completo, las \u00e1reas de las met\u00e1stasis y el \u00e1rea media de met\u00e1stasis originadas en un l\u00f3bulo y con ellos el porcentaje de implantaci\u00f3n = (\u00e1rea de met\u00e1stasis por l\u00f3bulo \/ \u00e1rea total) x 100, \u00edndice de crecimiento = \u00e1rea media de las met\u00e1stasis \/ \u00e1rea total e \u00edndice de invasi\u00f3n = \u00e1rea de met\u00e1stasis por l\u00f3bulo \/ \u00e1rea media de las met\u00e1stasis. Realizamos una estad\u00edstica descriptiva calculando la distribuci\u00f3n de frecuencias, media, error de la media y desviaci\u00f3n t\u00edpica, m\u00e1xima y m\u00ednima. La comparaci\u00f3n entre grupos con un an\u00e1lisis de varianza trasformando logar\u00edtmicamente los datos, compleme<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento del melanoma metastasico pulmonar, modelo esperimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento del melanoma metastasico pulmonar, modelo esperimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Martinez Conesa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Vicente Ortega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Lozano teruel Jos\u00e9 Antonio <\/li>\n<li>Emilio Mayayo artal (vocal)<\/li>\n<li>Antonio Bernabe salazar (vocal)<\/li>\n<li>Luis Fernando Oton sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Martinez Conesa Resumen realizamos el estudio de los efectos de seis compuestos fen\u00f3licos y el vino [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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