{"id":70729,"date":"2004-08-10T00:00:00","date_gmt":"2004-08-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/integracion-de-la-bioinformatica-en-la-investigacion-genomica-cardiovascular-aplicaciones-en-el-framingham-heart-study\/"},"modified":"2004-08-10T00:00:00","modified_gmt":"2004-08-10T00:00:00","slug":"integracion-de-la-bioinformatica-en-la-investigacion-genomica-cardiovascular-aplicaciones-en-el-framingham-heart-study","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/matematicas\/integracion-de-la-bioinformatica-en-la-investigacion-genomica-cardiovascular-aplicaciones-en-el-framingham-heart-study\/","title":{"rendered":"Integracion de la bioinformatica en la investigacion genomica cardiovascular. aplicaciones en el framingham heart study"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Oscar Coltell Simon <\/strong><\/h2>\n<p>El objetivo principal de esta tesis es la aplicaci\u00f3n integrada de enfoques metodol\u00f3-gicos de las disciplinas ingenier\u00eda del software y auditor\u00eda de sistemas de infor-maci\u00f3n a la bioinform\u00e1tica, en funci\u00f3n de la identificaci\u00f3n y caracterizaci\u00f3n de las aportaciones de esta disciplina a los trabajos de investigaci\u00f3n en el \u00e1rea de la epi-demiolog\u00eda gen\u00f3mica de las enfermedades cardiovasculares. Dado que el \u00e1mbito de aplicaci\u00f3n as\u00ed definido es demasiado amplio, se ha establecido un tema espec\u00edfi-co, el c\u00e1lculo del riesgo cardiovascular a escala individual, sobre el cual giran los trabajos de investigaci\u00f3n y se describen las aportaciones concretas de esta tesis.  el \u00e1mbito de la epidemiolog\u00eda gen\u00f3mica de las enfermedades cardiovascula-res est\u00e1 caracterizado por el framingham heart study (massachusetts, ee.Uu., 1948 -) y los factores de riesgo cardiovascular son de tipo gen\u00e9tico y ambiental. Dado que la lista actual de factores gen\u00e9ticos implicados en las enfermedades car-diovasculares contiene casi 3.000 genes, de la misma se han elegido un reducido subconjunto de los cuales se tiene informaci\u00f3n sobre sus polimorfismos y fenotipos patol\u00f3gicos: cetp, apoe, apoa1, lipc, sr-bi y plin. Este \u00faltimo gen tambi\u00e9n se ha estudiado comparativamente en poblaci\u00f3n general de la comunidad valen-ciana. Se ha desarrollado un estudio completo de cada uno de los genes relaciona-dos. Los resultados obtenidos permiten descubrir unas interesantes interacciones gen*ambiente, gen*sexo, gen*dieta, gen*diabetes 2 y gen*obesidad, asociados a los polimorfismos de los genes estudiados y que se identifican en cada estudio. En resumen, se ofrecen datos concretos de asociaciones reales observadas entre varia-ciones gen\u00e9ticas y fenotipos cardiovasculares, as\u00ed como de interacciones gen*ambiente.  en el \u00e1mbito de la bioinform\u00e1tica, se ha desarrollado un modelo para el c\u00e1l-culo del riesgo cardiovascular a escala individual y un modelo para la ap<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Integracion de la bioinformatica en la investigacion genomica cardiovascular. aplicaciones en el framingham heart study<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Integracion de la bioinformatica en la investigacion genomica cardiovascular. aplicaciones en el framingham heart study <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Oscar Coltell Simon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Jaume i de castell\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Toledo Lobo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ferran Sanz carreras <\/li>\n<li>Jos\u00e9 ignacio Gonz\u00e1lez arraez (vocal)<\/li>\n<li>Jos\u00e9 Manuel I\u00f1esta quereda (vocal)<\/li>\n<li>carmen Saiz s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Oscar Coltell Simon El objetivo principal de esta tesis es la aplicaci\u00f3n integrada de enfoques metodol\u00f3-gicos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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