{"id":70756,"date":"2018-03-09T23:15:17","date_gmt":"2018-03-09T23:15:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-citoprotector-de-hidroxitirosol-y-esteres-de-hidroxitirosilo-en-un-modelo-experimental-de-anoxia-reoxigenacion\/"},"modified":"2018-03-09T23:15:17","modified_gmt":"2018-03-09T23:15:17","slug":"efecto-citoprotector-de-hidroxitirosol-y-esteres-de-hidroxitirosilo-en-un-modelo-experimental-de-anoxia-reoxigenacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-citoprotector-de-hidroxitirosol-y-esteres-de-hidroxitirosilo-en-un-modelo-experimental-de-anoxia-reoxigenacion\/","title":{"rendered":"Efecto citoprotector de hidroxitirosol y \u00e9steres de hidroxitirosilo en un modelo experimental de anoxia-reoxigenaci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Enrique L\u00f3pez Torres <\/strong><\/h2>\n<p>Han sido ampliamente estudiadas los beneficios terap\u00e9uticos del aceite de oliva (disminuci\u00f3n en la oxidaci\u00f3n de las ldl-colesterol, aumento de la hdl-colesterol y su relaci\u00f3n positiva con la enfermedad vascular). Algunos de los principales compuestos de este aceite son los compuestos fen\u00f3licos, entre los que se destaca el hidroxitirosol por su gran potencia antioxidante y por su posible empleo como neuroprotector. Una de las caracter\u00edsticas del mismo est\u00e1 en su polaridad que condiciona su baja solubilidad en l\u00edpidos y por tanto su baja concentraci\u00f3n en el aceite de oliva.  el presente trabajo eval\u00faa desde un punto de vista farmacol\u00f3gico las propiedades antixoidantes en un modelo experimental de anoxia-reoxigenac\u00f3n, explorando las principales v\u00edas bioqu\u00edmicas relacionadas con el da\u00f1o tisular isqu\u00e9mico a nivel cerebral, del hidroxitirosol (ht), y dos de sus \u00e9steres, que aumentar\u00edan su liposolubilidad; acetato y oleato de  hidroxitirosilo.  para ello se emplearon 10 grupos de 8 ratas macho wistar (80 en total). los cuales fueron sometidas a un tratamiento distinto durante una semana: ht \u00f3 sus \u00e9steres (5 \u00f3 10 mg\/kg\/d\u00eda) y otro grupo tratado con vitamina e 100mg\/kg\/d\u00eda m\u00e1s grupo control. Se analizaron par\u00e1metros de estr\u00e9s oxidativo (mda, gsh, gt, %gssg\/gt, enzimas relacionadas) y par\u00e1metros de da\u00f1o celular (actividades inos, cnos, protaglandinas, peroxinitritos, nitratos-nitritosldh) tras una semana de tratamiento y tras haber sido sometidos los cerebros a un modelo de anoxia-reoxigenaci\u00f3n.  se pone de manifiesto una gran potencia de los compuestos analizados respecto a la inhibici\u00f3n in vitro de la peroxidaci\u00f3n lip\u00eddica siguiendo el siguiente orden: ht mayor acetato de hidroxitirosilo mayor oleato de hidroxitirosilo. en este sentido, adem\u00e1s de disminuir la peroxidaci\u00f3n lip\u00eddica de las membranas, aumentan de forma significativa las defensas antioxidantes (sistema del glutation) celulares. Por otro lado se obs<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto citoprotector de hidroxitirosol y \u00e9steres de hidroxitirosilo en un modelo experimental de anoxia-reoxigenaci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto citoprotector de hidroxitirosol y \u00e9steres de hidroxitirosilo en un modelo experimental de anoxia-reoxigenaci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Enrique L\u00f3pez Torres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez Correa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francesc Jan\u00e9 carrenca <\/li>\n<li>m isabel Lucena gonzalez (vocal)<\/li>\n<li>felipe Alcudia gonzalez (vocal)<\/li>\n<li>amadeu Gavald\u00e1 monedero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Enrique L\u00f3pez Torres Han sido ampliamente estudiadas los beneficios terap\u00e9uticos del aceite de oliva (disminuci\u00f3n en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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