{"id":70771,"date":"2018-03-09T23:15:17","date_gmt":"2018-03-09T23:15:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-expresion-genica-en-el-tejido-adiposo-blanco-de-ratas-alimentadas-con-una-dieta-rica-en-grasas\/"},"modified":"2018-03-09T23:15:17","modified_gmt":"2018-03-09T23:15:17","slug":"analisis-de-la-expresion-genica-en-el-tejido-adiposo-blanco-de-ratas-alimentadas-con-una-dieta-rica-en-grasas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analisis-de-la-expresion-genica-en-el-tejido-adiposo-blanco-de-ratas-alimentadas-con-una-dieta-rica-en-grasas\/","title":{"rendered":"Analisis de la expresion genica en el tejido adiposo blanco de ratas alimentadas con una dieta rica en grasas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Iciar Paula Lopez Garcia <\/strong><\/h2>\n<p>El objetivo de este trabajo ha sido la identificaci\u00f3n de genes que resultan espec\u00edficamente activados y\/o reprimidos en el tejido adiposo blanco de ratas durante las primeras etapas del desarrollo de la obesidad inducida por una alimentaci\u00f3n con una dieta hipercal\u00f3rica rica en grasas (dieta de cafeter\u00eda). Para ello se ha empleado la t\u00e9cnica conocida como rna fingerprint o differential display. Adem\u00e1s se ha estudiado la evoluci\u00f3n del patr\u00f3n de expresi\u00f3n de los genes identificados en el objetivo anterior, en etapas m\u00e1s avanzadas del desarrollo de la obesidad producida por el mantenimiento durante un tiempo prolongado de la dieta hipercal\u00f3rica. Para ello se ha empleado la metodolog\u00eda de a hibridaci\u00f3n de microarrays de dna. En ambos casos s\u00f3lo se han secuenciado aquellos productos cuya expresi\u00f3n diferencial pudo ser confirmada mediante northern blot en m\u00e1s animales. Finalmente, han sido 20 el n\u00famero de genes identificados que pueden clasificarse de la siguiente manera: a) metabolismo lip\u00eddico: adiponectina, caveolina 2, y lactato deshidrogenasa a b) metabolismo del hierro: transferrina c) factor de transcripci\u00f3n: prote\u00edna de uni\u00f3n a los \u00e1cidos nucleicos yb-1 \u00aby box protein 1&#8243;d) citoesqueleto: fibrilinal y distroglicanol e) prote\u00ednas ribosomales: l7 y s10 f) genes mitocondriales: rrna 16s y la subunidad i de la citocromo oxidas cox i) junto con trna de la serina. G) cadena 6 del receptor de la inmunoglobulina e (fcerir) h) cadena alfa-1 de la hemoglobina (hbal) i) genes similares a otros genes de rata conocidos, como el lim domain binding factor-1, el factor espec\u00edfico de osteoblastos 2 (osf2) y la prote\u00edna sobreexpresada asociada con la resistencia a cisplatino (crop) .:)) Genes que presentan homolog\u00eda con otros no caracterizados: un cdna repirmido en tumores de gl\u00e1ndula mamaria de rata (rat mammary tumor 7, tmt7), y un cdna de rat\u00f3n sin caracterizar. K) genes no identificados sin homolog\u00eda con genes conocidos: dos est de rata.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis de la expresion genica en el tejido adiposo blanco de ratas alimentadas con una dieta rica en grasas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis de la expresion genica en el tejido adiposo blanco de ratas alimentadas con una dieta rica en grasas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Iciar Paula Lopez Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Gabriel De Miguel Vazquez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 alfredo Martinez hernandez <\/li>\n<li>Antonio Martinez Martinez (vocal)<\/li>\n<li>angel Gil hernandez (vocal)<\/li>\n<li>Francisco Jos\u00e9 S\u00e1nchez mu\u00f1iz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Iciar Paula Lopez Garcia El objetivo de este trabajo ha sido la identificaci\u00f3n de genes que resultan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,467,35,17749],"tags":[3791,63480,17801,24096,154417,18195],"class_list":["post-70771","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-ciencias-de-la-nutricion","category-ciencias-de-la-vida","category-navarra","tag-angel-gil-hernandez","tag-antonio-Martinez-Martinez","tag-carlos-gabriel-de-miguel-vazquez","tag-francisco-jose-sanchez-muniz","tag-iciar-paula-lopez-garcia","tag-jose-alfredo-Martinez-hernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=70771"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/70771\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=70771"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=70771"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=70771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}