{"id":70825,"date":"2018-03-09T23:15:21","date_gmt":"2018-03-09T23:15:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/coexpresion-de-las-proteinas-precursora-del-amiloide-y-tau-humanas-mutadas-en-cerebro-de-ratones-transgenicos-como-modelo-in-vivo-de-enfermedad-de-alzheimer\/"},"modified":"2018-03-09T23:15:21","modified_gmt":"2018-03-09T23:15:21","slug":"coexpresion-de-las-proteinas-precursora-del-amiloide-y-tau-humanas-mutadas-en-cerebro-de-ratones-transgenicos-como-modelo-in-vivo-de-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/coexpresion-de-las-proteinas-precursora-del-amiloide-y-tau-humanas-mutadas-en-cerebro-de-ratones-transgenicos-como-modelo-in-vivo-de-enfermedad-de-alzheimer\/","title":{"rendered":"Coexpresion de las proteinas precursora del amiloide y tau humanas mutadas en cerebro de ratones transgenicos como modelo in vivo de enfermedad de alzheimer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Mar\u00eda Ribe Garrido <\/strong><\/h2>\n<p>A pesar de que la idea de que la acumulaci\u00f3n del p\u00e9ptido amiloide es un evento primario en la patogenia de la enfermedad de alzheimer, el nexo causal entre el procesamiento an\u00f3malo de la prote\u00ed\u00afna precursora del amiloide y las alteraciones en tau se desconoce.   En este trabajo se ha estudiado el papel   que el p\u00e9ptido amiloide (ar) ejerce en la aparici\u00f3n de la patolog\u00eda tau y su implicaci\u00f3n en la muerte neuronal en el cerebro de ratones de una linea nueva doble transg\u00e9nica basada en el cruce de las lineas tg 2576 y vlw. Estos ratones doble transg\u00e9nicos muestran un incremento acusado en la cantidad de amiloide despositado en comparaci\u00f3n con la linea parental tg 2576, hiperfosforilaci\u00f3n de tau as\u00ed como ovillos neurofibrilares y p\u00e9rdida significativa de neuronas en regiones cerebrales selectivamente vulnerables en la enfermedad de alzheimer en humanos. Estos hallazgos desaf\u00edan la idea de que la patolog\u00eda tau es una mera consecuencia del desequilibrio entre producci\u00f3n y dep\u00f3sito de amiloide y sugiere la existencia in vivo de interacciones rec\u00edprocas entre ais y tau.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Coexpresion de las proteinas precursora del amiloide y tau humanas mutadas en cerebro de ratones transgenicos como modelo in vivo de enfermedad de alzheimer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Coexpresion de las proteinas precursora del amiloide y tau humanas mutadas en cerebro de ratones transgenicos como modelo in vivo de enfermedad de alzheimer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Mar\u00eda Ribe Garrido <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Teresa Gomez Isla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Martinez <\/li>\n<li>Manuel Sarasa barrio (vocal)<\/li>\n<li>Jos\u00e9 Rodrigo garcia (vocal)<\/li>\n<li>olga Diaz de rada pardo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Mar\u00eda Ribe Garrido A pesar de que la idea de que la acumulaci\u00f3n del p\u00e9ptido amiloide [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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