{"id":70837,"date":"2018-03-09T23:15:21","date_gmt":"2018-03-09T23:15:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-de-las-citocinas-reguladoras-de-la-actividad-osteoclastica-en-la-enfermedad-osea-de-paget-eop\/"},"modified":"2018-03-09T23:15:21","modified_gmt":"2018-03-09T23:15:21","slug":"polimorfismos-de-las-citocinas-reguladoras-de-la-actividad-osteoclastica-en-la-enfermedad-osea-de-paget-eop","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismos-de-las-citocinas-reguladoras-de-la-actividad-osteoclastica-en-la-enfermedad-osea-de-paget-eop\/","title":{"rendered":"Polimorfismos de las citocinas reguladoras de la actividad osteocl\u00e1stica en la enfermedad osea de paget (eop)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Corral Gudino <\/strong><\/h2>\n<p>Introducci\u00f3n  la enfermedad \u00f3sea de paget (eop) es una enfermedad cr\u00f3nica y focal del esqueleto cuya alteraci\u00f3n inicial est\u00e1 localizada en los osteoclastos. las citocinas il-1 e il-6 desempe\u00f1an un importante papel en el remodelado \u00f3seo, modulando la diferenciaci\u00f3n y actividad osteocl\u00e1stica, por lo que su estudio podr\u00eda aportar datos a la etiopatogenia de la eop.  objetivos  &#8211;  establecer las caracter\u00edsticas cl\u00ednicas de la eop en un foco de alta preValencia.  &#8211;  describir la respuesta al tratamiento en una cohorte hist\u00f3rica.  &#8211;  valorar la relaci\u00f3n entre distintos polimorfismos de il1 e il6 y la eop.  material y m\u00e9todo  se estudiaron 211 pacientes (35% procedentes del foco de alta preValencia correspondiente al partido judicial de vitigudino [salamanca]). Se obtuv\u00f3 muestra de sangre perif\u00e9rica de 126 de estos pacientes para posterior estudio del dna mediante pcr-rflp. Se seleccion\u00f3 como grupo control a 122 individuos sin enfermedad metab\u00f3lica \u00f3sea conocida.  resultados y conclusiones  &#8211;  los pacientes pertenecientes al foco de alta preValencia de vitigudino tienen formas cl\u00ednicas m\u00e1s graves de eop, son diagnosticados m\u00e1s tempranamente y presentan un mayor porcentaje de hombres que los pacientes del resto de la provincia de salamanca.  &#8211;  la eficacia del tratamiento con calcitonina es inferior a la de cualquier bifosfonato y existe una tendencia a una mejor respuesta de la eop al tratamiento con bifosfonatos nitrogenados.  &#8211;  la presencia del alelo a2 del polimorfismo -511 c\/t en la regi\u00f3n promotora del gen de la il-1b se asocia a una mejor respuesta al tratamiento con bifosfonatos.  &#8211;  no encontramos relaci\u00f3n entre los polimorfismos +3953 t\/c en el ex\u00f3n 5 del gen de la il-1b, vntr en el intr\u00f3n 2 del gen del il1-rn, en la regi\u00f3n 5\u00c2\u00bfutr del gen del il-1 r1 y el -174 g\/c en la regi\u00f3n promotora del gen de la il-6 y la eop.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos de las citocinas reguladoras de la actividad osteocl\u00e1stica en la enfermedad osea de paget (eop)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos de las citocinas reguladoras de la actividad osteocl\u00e1stica en la enfermedad osea de paget (eop) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Corral Gudino <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>JavierDel Pino Montes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Miralles garcia Jos\u00e9 manuel <\/li>\n<li>teresita Bellido (vocal)<\/li>\n<li>Manuel Mu\u00f1oz torres (vocal)<\/li>\n<li>Jos\u00e9 Luis P\u00e9rez castrill\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Corral Gudino Introducci\u00f3n la enfermedad \u00f3sea de paget (eop) es una enfermedad cr\u00f3nica y focal del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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