{"id":70891,"date":"2018-03-09T23:15:25","date_gmt":"2018-03-09T23:15:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/especificacion-del-borde-notum-axila-dorsal-en-drosophila-melanogaster-funcion-de-los-genes-msh-e-iroquois\/"},"modified":"2018-03-09T23:15:25","modified_gmt":"2018-03-09T23:15:25","slug":"especificacion-del-borde-notum-axila-dorsal-en-drosophila-melanogaster-funcion-de-los-genes-msh-e-iroquois","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/especificacion-del-borde-notum-axila-dorsal-en-drosophila-melanogaster-funcion-de-los-genes-msh-e-iroquois\/","title":{"rendered":"Especificaci\u00f3n del borde notum-axila dorsal en drosophila melanogaster. funci\u00f3n de los genes msh e iroquois"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Villa Cuesta M\u00aa Eugenia <\/strong><\/h2>\n<p>Los bordes morfogen\u00e9ticos permiten que las c\u00e9lulas de una misma poblaci\u00f3n celular se separen en distintos territorios. En el disco de ala de drosophila melanogaster existe un borde que separa el primordio de notum del de axila dorsal. La especificaci\u00f3n de este borde se desconoce, as\u00ed los objetivos de esta tesis han sido ayudar a entender como se establece esta subdivisi\u00f3n, y para ello, analizamos la funci\u00f3n de los genes muscle segment homeobox (msh) e iroquois.  el gen  msh codifica para un factor de transcripci\u00f3n tipo homeoprote\u00edna cuyo patr\u00f3n de expresi\u00f3n est\u00e1 limitado desde temprano en el desarrollo al primordio de axila dorsal, este patr\u00f3n es adyacente pero no solapante al patr\u00f3n de expresi\u00f3n de los genes iroquios( que codifican tambi\u00e9n para factores de transcripci\u00f3n tipo homeoprote\u00ednas) en el primordio de notum. nuestros estudios muestran que el mantenimiento de la frontera entre ambos dominios de expresi\u00f3n se produce por una represi\u00f3n mutua de ambas homeoprote\u00ednas. mediante experimentos de sobreexpresi\u00f3n y falta de funci\u00f3n del gen msh en la tesis se muestra que msh es adem\u00e1s imprescindible para el correcto desarrollo de la axila alar, del notum y del patr\u00f3n de \u00f3rganos sensoriales del notum. Todos estos resultados permiten concluir que el borde notum-axila dorsal se establece y\/o mantiene por represi\u00f3n mutua entre msh e iroquois. esta represi\u00f3n parece ser directa al mentos para iroquois puesto que an\u00e1lisis in vitro e in vivo muestran  que las prote\u00ednas iroquois se unen al adn de msh.  la represi\u00f3n mutua entre prote\u00ednas con homeodominio es un mecanismo frecuente en la subdivisi\u00f3n del cerebro de vertebrados, adem\u00e1s, hom\u00f3logos a iroquois en vertebrados intervienen en la formaci\u00f3n de bordes morfogen\u00e9ticos. Se enfatiza pues en la tesis, que el mecanismo mediante el cual se mantiene la separaci\u00f3n entre el notum y la axila dorsal en el disco de ala de drosophila melanogaster es un mecanismo conservado<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Especificaci\u00f3n del borde notum-axila dorsal en drosophila melanogaster. funci\u00f3n de los genes msh e iroquois<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Especificaci\u00f3n del borde notum-axila dorsal en drosophila melanogaster. funci\u00f3n de los genes msh e iroquois <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Villa Cuesta M\u00aa Eugenia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Modolell Mainou<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Garc\u00eda-bellido Garc\u00eda de diego Antonio <\/li>\n<li>marco Milan kalbfleisch (vocal)<\/li>\n<li>Jes\u00fas Avila de grado (vocal)<\/li>\n<li> D\u00edez del corral ruth (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Villa Cuesta M\u00aa Eugenia Los bordes morfogen\u00e9ticos permiten que las c\u00e9lulas de una misma poblaci\u00f3n celular se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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