{"id":70916,"date":"2018-03-09T23:15:29","date_gmt":"2018-03-09T23:15:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-del-estado-oxidativo-en-pacientes-con-artritis-reumatoide-correlacion-cla%c2%adnico-bioqua%c2%admica\/"},"modified":"2018-03-09T23:15:29","modified_gmt":"2018-03-09T23:15:29","slug":"valoracion-del-estado-oxidativo-en-pacientes-con-artritis-reumatoide-correlacion-cla%c2%adnico-bioqua%c2%admica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valoracion-del-estado-oxidativo-en-pacientes-con-artritis-reumatoide-correlacion-cla%c2%adnico-bioqua%c2%admica\/","title":{"rendered":"Valoraci\u00f3n del estado oxidativo en pacientes con artritis reumatoide: correlaci\u00f3n cl\u00ednico-bioqu\u00edmica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco  De Paula Gabriel Jim\u00e9nez N\u00fa\u00f1ez <\/strong><\/h2>\n<p>En la \u00faltima d\u00e9cada se ha avanzado mucho en el conocimiento de la fisiopatolog\u00eda de la artritis reumatoide (ar), en la que la implicaci\u00f3n de los radicales libres ha quedado demostrada. Hoy d\u00eda sabemos que los radicales libres est\u00e1n implicados en la etiopatogenia de muchas enfermedades. La relaci\u00f3n directa con el proceso inflamatorio y su influencia sobre diversa actividades enzim\u00e1ticas contribuyen a potenciar del estudio del estado oxidativo como patr\u00f3n bioqu\u00edmico predictor de la evoluci\u00f3n de diversas patolog\u00edas. El estudio de  la etipatogenia de la ar, centrado en los cambio acontecidos sobre las v\u00edas bioqu\u00edmicas relacionadas con el estado oxidativo, permitir\u00e1 avanzar en el conocimiento sobre nuevas estrategias terap\u00e9uticas.  en este sentido, los objetivos del trabajo fueron: evaluar el estado oxidativo perif\u00e9rico en enfermos con ar, correlacionando los resultados obtenidos con el grado de actividad inflamatoria y evoluci\u00f3n de la enfermedad y valorar la relaci\u00f3n entre comorbilidades y ar.  para ello se realiz\u00f3 un estudio observacional, descriptivo, transversal de una poblaci\u00f3n con ar (68 pacientes) (frente a grupo control sano, n=30) (consulta de reumatolog\u00eda ch carlos haya). Se extrajeron 15 ml de sangre a cada paciente. Se procedi\u00f3 a la separaci\u00f3n de plasma y hemat\u00edes. Posteriormente se midieron los par\u00e1metros relacionados con el estr\u00e9s oxidativo: mda, glutation y actividades relacionadas con el glutation, sod. Correlaci\u00f3n de los par\u00e1metros cl\u00ednicos y bioqu\u00edmicos.  las caracter\u00edsticas demogr\u00e1ficas de la poblaci\u00f3n fueron similares a los de otros estudios realizados (edad, sexo, actividad y evoluci\u00f3n de la enfermedad). los enfermos de ar del estudio presentaron un desequilibrio del estado oxidativo con un incremento en la peroxidaci\u00f3n lip\u00eddica y disminuci\u00f3n de la defensa antioxidante; disminuci\u00f3n del glutati\u00f3n reducido y actividades enzim\u00e1ticas glutation-px y glutation-rd, as\u00ed como una disminuci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valoraci\u00f3n del estado oxidativo en pacientes con artritis reumatoide: correlaci\u00f3n cl\u00ednico-bioqu\u00edmica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valoraci\u00f3n del estado oxidativo en pacientes con artritis reumatoide: correlaci\u00f3n cl\u00ednico-bioqu\u00edmica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco  De Paula Gabriel Jim\u00e9nez N\u00fa\u00f1ez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez Correa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: david (secretario) Ruiz villafranca <\/li>\n<li>Jos\u00e9 Mario sabio (vocal)<\/li>\n<li>Rafael C\u00e1liz c\u00e1liz (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco De Paula Gabriel Jim\u00e9nez N\u00fa\u00f1ez En la \u00faltima d\u00e9cada se ha avanzado mucho en el conocimiento [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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