{"id":70925,"date":"2018-03-09T23:15:29","date_gmt":"2018-03-09T23:15:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estres-reticular-calcio-y-apoptosis-en-celulas-de-neuroblastoma-efectos-del-suero-y-de-la-albumina\/"},"modified":"2018-03-09T23:15:29","modified_gmt":"2018-03-09T23:15:29","slug":"estres-reticular-calcio-y-apoptosis-en-celulas-de-neuroblastoma-efectos-del-suero-y-de-la-albumina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estres-reticular-calcio-y-apoptosis-en-celulas-de-neuroblastoma-efectos-del-suero-y-de-la-albumina\/","title":{"rendered":"Estr\u00e9s reticular, calcio y apoptosis en c\u00e9lulas de neuroblastoma: efectos del suero y de la alb\u00famina"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gallego Sand\u00edn Sonia Mar\u00eda <\/strong><\/h2>\n<p>En los pa\u00edses desarrollados, las enfermedades neurodegenerativas constituyen un serio problema sanitario y social, ya que son la primera causa de secuelas neurol\u00f3gicas y minusval\u00edas f\u00edsicas. El alzheimer es una enfermedad neurodegenerativa que se caracteriza por una p\u00e9rdida progresiva de la memoria y otras funciones cognitivas. El curso de esta patolog\u00eda, como el de otras enfermedades neurodegenerativas, lleva a la incapacidad f\u00edsica y mental de los pacientes, que pasan a ser totalmente dependientes de sus cuidadores. Las lesiones neurol\u00f3gicas producidas tras un accidente cerebrovascular tambi\u00e9n constituyen un problema de salud importante. Esta patolog\u00eda afecta sin embargo a individuos de todas las edades, aunque la incidencia tambi\u00e9n se incrementa con la edad.  los datos que obtenemos en este trabajo tambi\u00e9n podemos relacionar las variaciones del re con cambios en la mitocondria y verificamos, al igual que otros autores (h\u00ed\u00a4cki y col., 2000), que agentes que interfieren con la funci\u00f3n del re inducen despolarizaci\u00f3n mitocondrial y probablemente la liberaci\u00f3n del citocromo c y la consiguiente activaci\u00f3n de la caspasa 3 y de la ruta intr\u00ednseca de la apoptosis celular. La despolarizaci\u00f3n de las mitocondrias es m\u00e1s patente en ausencia de suero; aunque en presencia de suero tambi\u00e9n se observa este fen\u00f3meno. Posiblemente el suero y la alb\u00famina est\u00e1n protegiendo a la mitocondria activando el metabolismo de este org\u00e1nulo, impidiendo que se despolarice, se desacople la fosforilaci\u00f3n oxidativa y se paralice la s\u00edntesis de atp. En los \u00faltimos a\u00f1os, la conservaci\u00f3n de la homeostasia del ca2+ del ret\u00edculo endoplasm\u00e1tico ha emergido como un mecanismo cr\u00edtico para el mantenimiento de la funci\u00f3n de este org\u00e1nulo. la alteraci\u00f3n de la [ca2+]re desencadena una respuesta de estr\u00e9s reticular que participa en la neurodegeneraci\u00f3n celular y conlleva a la muerte neuronal en enfermedades neurodegenerativas y en la isquemia cer<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estr\u00e9s reticular, calcio y apoptosis en c\u00e9lulas de neuroblastoma: efectos del suero y de la alb\u00famina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estr\u00e9s reticular, calcio y apoptosis en c\u00e9lulas de neuroblastoma: efectos del suero y de la alb\u00famina <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gallego Sand\u00edn Sonia Mar\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Garc\u00eda Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>valent\u00edn Ce\u00f1a (vocal)<\/li>\n<li> Montero zoccola M\u00aa teresa (vocal)<\/li>\n<li>joan xavier Comella carnice (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gallego Sand\u00edn Sonia Mar\u00eda En los pa\u00edses desarrollados, las enfermedades neurodegenerativas constituyen un serio problema sanitario y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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