{"id":71006,"date":"2018-03-09T23:15:32","date_gmt":"2018-03-09T23:15:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/significado-cla%c2%adnico-patologico-de-la-concentracion-citosolica-de-catepsina-d-en-el-cancer-gastrico\/"},"modified":"2018-03-09T23:15:32","modified_gmt":"2018-03-09T23:15:32","slug":"significado-cla%c2%adnico-patologico-de-la-concentracion-citosolica-de-catepsina-d-en-el-cancer-gastrico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/significado-cla%c2%adnico-patologico-de-la-concentracion-citosolica-de-catepsina-d-en-el-cancer-gastrico\/","title":{"rendered":"Significado cl\u00ednico-patol\u00f3gico de la concentraci\u00f3n citos\u00f3lica de catepsina d en el c\u00e1ncer g\u00e1strico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Casar Lizcano Jos\u00e9 Manuel Del <\/strong><\/h2>\n<p>Resumen  la catepsina d es una aspartil-proteasa involucrada en el catabolismo proteico y la remodelaci\u00f3n tisular. En esta tesis doctoral evaluamos las concentraciones intratumorales de catepsina d en el c\u00e1ncer g\u00e1strico, su relaci\u00f3n con par\u00e1metros cl\u00ednico-patol\u00f3gicos, as\u00ed como tambi\u00e9n su significado pron\u00f3stico.  material y m\u00e9todos  este estudio prospectivo incluye una serie de 133 pacientes con adenocarcinoma g\u00e1strico primario sometido a intervenci\u00f3n quir\u00fargica de sus tumores. Se evalu\u00f3 la recurrencia tumoral y la supervivencia durante un  periodo medio de seguimiento de 27 meses. La catepsina d fue determinada en el citosol de las muestras tumorales mediante an\u00e1lisis inmuno-radiom\u00e9trico, que determin\u00f3 la cantidad total de catepsina d (52k, 48k y34k).  resultados  las concentraciones intratumorales de catepsina d variaron de 4 a 1434,9 pmol\/mg de prote\u00edna, y de 1 a 136,7 pmo\/mg de prote\u00edna en las muestras de mucosa g\u00e1strica adyacente a los tumores. El contenido de catepsina d fue significativamente m\u00e1s elevado en el tejido neopl\u00e1sico (mediana;: 41,9, intervalo: 4-1434,p pmol\/mg prote\u00edna) que en las muestras de mucosa adyacente (mediana: 28,8 intervalo: 1-136,7 pmol\/mg prote\u00edna) (p menor 0,001).  el an\u00e1lisis estad\u00edstico tambi\u00e9n demostr\u00f3 que los pacientes con niveles intratumorales elevados de catepsina d tuvieron una supervivencia significativamente m\u00e1s corta que aquellos con niveles m\u00e1s bajos del a proteasa, tanto en el conjunto de los pacientes como en aquellos con tumores quir\u00fargicamente resecables (p menor 0,01 y p menor 0,001, respectivamente). Adem\u00e1s la catepsina d fue un factor pron\u00f3stico independiente en el an\u00e1lisis multivariante (p menor 0,02).  conclusiones  las concentraciones intratumorales de catepsina d m\u00e1s elevadas que las presentes en la mucosa g\u00e1strica no neopl\u00e1sica sugieren un papel de la proteasa en la transformaic\u00f3n maligna del epitelio g\u00e1strico. Asimismo, los niveles i<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Significado cl\u00ednico-patol\u00f3gico de la concentraci\u00f3n citos\u00f3lica de catepsina d en el c\u00e1ncer g\u00e1strico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Significado cl\u00ednico-patol\u00f3gico de la concentraci\u00f3n citos\u00f3lica de catepsina d en el c\u00e1ncer g\u00e1strico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Casar Lizcano Jos\u00e9 Manuel Del <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Fuevo Silva<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Viiande v\u00e1zquez <\/li>\n<li>Mar\u00eda  del mar Abad hernandez (vocal)<\/li>\n<li>jaume Fern\u00e1ndez llamazares rodriguez (vocal)<\/li>\n<li>Manuel Garcia moran lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Casar Lizcano Jos\u00e9 Manuel Del Resumen la catepsina d es una aspartil-proteasa involucrada en el catabolismo proteico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,387,8846],"tags":[154855,154854,14217,122734,154856,60434],"class_list":["post-71006","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-abdominal","category-oviedo","tag-antonio-fuevo-silva","tag-casar-lizcano-jose-manuel-del","tag-jaume-fernandez-llamazares-rodriguez","tag-manuel-garcia-moran-lopez","tag-manuel-viiande-vazquez","tag-maria-del-mar-abad-hernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71006","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71006"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71006\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71006"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71006"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71006"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}