{"id":71007,"date":"2018-03-09T23:15:32","date_gmt":"2018-03-09T23:15:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-la-e-cadherina-cd44h-y-cd44v6-en-carcinomas-epidermoides-lara%c2%adngeos-supragloticos-y-su-correlacion-con-los-parametros-cla%c2%adnico-patologicos\/"},"modified":"2018-03-09T23:15:32","modified_gmt":"2018-03-09T23:15:32","slug":"expresion-de-la-e-cadherina-cd44h-y-cd44v6-en-carcinomas-epidermoides-lara%c2%adngeos-supragloticos-y-su-correlacion-con-los-parametros-cla%c2%adnico-patologicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-de-la-e-cadherina-cd44h-y-cd44v6-en-carcinomas-epidermoides-lara%c2%adngeos-supragloticos-y-su-correlacion-con-los-parametros-cla%c2%adnico-patologicos\/","title":{"rendered":"Expresi\u00f3n de la e-cadherina, cd44h y cd44v6 en carcinomas epidermoides lar\u00edngeos supragl\u00f3ticos y su correlaci\u00f3n con los par\u00e1metros cl\u00ednico-patol\u00f3gicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Manrique Estrada M. Covadonga <\/strong><\/h2>\n<p>Se estudian 101 pacientes con carcinoma epidermoide lar\u00edngeo de localizaci\u00f3n supragl\u00f3tica, primarios y sin met\u00e1stasis a distancia. Todos ellos fueron tratados mediante resecci\u00f3n quir\u00fargica del tumor y vaciamiento ganglionar cervical bilateral. Se administr\u00f3 tratamiento complementario con radioterapia en aproximadamente la midad de los casos, generalmente en los casos localmente avanzados y\/o con met\u00e1stasis ganglionares m\u00faltiples. Se estudi\u00f3 la expresi\u00f3n de las mol\u00e9culas de adhesi\u00f3n e-cadherina, cd44s y cd44v6 mediante t\u00e9cnicas de inmunohistoqu\u00edmica con anticuerpos monoclonales en las muestras tumorales recuperadas de los archivos patol\u00f3gicos utilizando un sistema de pol\u00edmeros de dextrano. Las preparaciones fueron estudiadas asginando una puntuaci\u00f3n a cada una de ellas bas\u00e1ndose en dos par\u00e1metros para medir la inmunoreactividad: la intensidad de tinci\u00f3n de la membrana (1 a 4) y el porcentaje de c\u00e9lulas te\u00f1idas en cada muestra. El epitelio lar\u00edngeo normal present\u00f3 un patr\u00f3n de expresi\u00f3n similar a las tres mol\u00e9culas de adhesi\u00f3n, con una tinci\u00f3n intensa de todo el espesor de la membrana plasm\u00e1tica, de forma que la puntuaci\u00f3n media obtenida de la tinci\u00f3n fue de 368 para la e-cadherina, de 389 para la cd44s y de 395 para la cd44v6. Los tumores mostraron, como regla general, de forma que la puntuaci\u00f3n media (+- desviaci\u00f3n est\u00e1ndar) de tinci\u00f3n para los tumores fue de 136 +- 109 (mediana 100) para la e-cadherina, de 152 +- 119 (mediana 135) para la cd44s, y de 216 +- 127 (mediana 240) para la cdd44v6. La disminuci\u00f3n de la expresi\u00f3n de cd44s y cd44v6 se correlacion\u00f3 de forma significativa con un grado bajo de diferenciaci\u00f3n histol\u00f3gica (p=0,036 y p=0,001). La disminuci\u00f3n de la expresi\u00f3n de la e-cadherina se asoci\u00f3 con la presencia de met\u00e1stasis ganglionares (p=0,007) , as\u00ed como los estadios t avanzados (p=0,025) y un bajo grado de diferenciaci\u00f3n histol\u00f3gica (p=0,043). La combinaci\u00f3n de los tres par\u00e1me<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n de la e-cadherina, cd44h y cd44v6 en carcinomas epidermoides lar\u00edngeos supragl\u00f3ticos y su correlaci\u00f3n con los par\u00e1metros cl\u00ednico-patol\u00f3gicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n de la e-cadherina, cd44h y cd44v6 en carcinomas epidermoides lar\u00edngeos supragl\u00f3ticos y su correlaci\u00f3n con los par\u00e1metros cl\u00ednico-patol\u00f3gicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Manrique Estrada M. Covadonga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodrigo Tapia Juan  Pablo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Suares nieto <\/li>\n<li>miquel Quer agust\u00ed (vocal)<\/li>\n<li>Luis Mar\u00eda Gil carcedo Garc\u00eda (vocal)<\/li>\n<li>agustin Herrero zapatero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manrique Estrada M. Covadonga Se estudian 101 pacientes con carcinoma epidermoide lar\u00edngeo de localizaci\u00f3n supragl\u00f3tica, primarios y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8901,9,141,1543,8846,156],"tags":[9185,154858,6733,154857,85240,25571],"class_list":["post-71007","post","type-post","status-publish","format-standard","hentry","category-carcinogenesis","category-ciencias-medicas","category-cirugia","category-cirugia-de-garganta-nariz-y-oidos","category-oviedo","category-patologia","tag-agustin-herrero-zapatero","tag-carlos-suares-nieto","tag-luis-maria-gil-carcedo-garcia","tag-manrique-estrada-m-covadonga","tag-miquel-quer-agusti","tag-rodrigo-tapia-juan-pablo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71007","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71007"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71007\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71007"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71007"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}