{"id":71008,"date":"2018-03-09T23:15:32","date_gmt":"2018-03-09T23:15:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-cromosomicas-en-los-adenocarcinomas-nasosinusales-estudio-por-hibridacion-genomica-comparativa\/"},"modified":"2018-03-09T23:15:32","modified_gmt":"2018-03-09T23:15:32","slug":"alteraciones-cromosomicas-en-los-adenocarcinomas-nasosinusales-estudio-por-hibridacion-genomica-comparativa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-cromosomicas-en-los-adenocarcinomas-nasosinusales-estudio-por-hibridacion-genomica-comparativa\/","title":{"rendered":"Alteraciones cromos\u00f3micas en los adenocarcinomas nasosinusales. estudio por hibridacion gen\u00f3mica comparativa."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lucia Baraga\u00f1o Rio <\/strong><\/h2>\n<p>Se estudian 24 pacientes con adenocarcinoma nasosinusal mediante hibridaci\u00f3n gen\u00f3mica comparativa (hgc). La hgc es la hibridaci\u00f3n de adn de tejido sano y tumoral, marcados con fluorocromos diferentes, sobre metafases normales.  posteriormente los resultados se estudian mediante an\u00e1lisis de imagen digitales especiales. Todos los pacientes estudiados eran varones, 75% con exposici\u00f3n al polvo de la madera durante una media de 25 a\u00f1os. La cl\u00ednica de inicio fue en el 88% de ellos insuficiencia respiratoria nasal. El estudio anatomopatol\u00f3gico demostr\u00f3 un 100% de tipo mucoalveolar. En todos los casos se realiz\u00f3 exploraci\u00f3n f\u00edsica bajo anestesia local o general con toma de biopsia para estudio anatomopatol\u00f3gico. El estudio de imagen radiogr\u00e1fico se realiz\u00f3 con tac asociado en 4 de ellos rnm. A todos ellos se les realiz\u00f3 cirug\u00eda con intenci\u00f3n curativa, asociando en el 67% radioterapia. En las revisiones posteriores se objetiv\u00f3 recidiva local en el 67% de los pacientes, de los que 38% recibieron tratamiento paliativo yel 62% cirug\u00eda de rescate, asociada en el 60% de ellos a radioterapia. La supervivencia global fue del 48,45% a los 5 a\u00f1os. el estudio mediante hgc mostr\u00f3 en todos los casos ganancias y p\u00e9rdidas o delecciones y en el 62,5% de los casos amplificaciones. Las ganacias se localizaron con mayor frecuencia en: 7qll (70,8%), 8qll (66,6%), 7qll-21 yx (58,3%), 19p y20q (50%), 18pll y19 (45,8%), 5p13-11, 8qll-22, 12qll-13 (41,6%) y3q26-27 (37,5%) y p\u00e9rdidas en 18q22-23 (75%), 8p23 (66,6%), 8p23-22 (58,3%), 8p23-21 y 17p13 (37,5%), 5q31-35 y 17p(33,3%) y 18q y 5q (25%). a parte de las ganancias, el 65% de los pacientes tienen amplificaciones particularmente en: xq13 (29,2%), xq12 (20,8%), xq23 y xq25 (16,6%) y 7qll, l2p13, 20qll,y xq (12,5%). En el 25% de los pacientes se observa la formaci\u00f3n de isocromosomas, los m\u00e1s frecuentes 5p \/5q (20,8%), 8q \/8p (12,5%) y17q \/17p (8,3%). La hgc para conocer las alteraciones cromos<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones cromos\u00f3micas en los adenocarcinomas nasosinusales. estudio por hibridacion gen\u00f3mica comparativa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones cromos\u00f3micas en los adenocarcinomas nasosinusales. estudio por hibridacion gen\u00f3mica comparativa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lucia Baraga\u00f1o Rio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Llorente Pendas Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Suarez nieto <\/li>\n<li>miquel Quer agust\u00ed (vocal)<\/li>\n<li>Luis Mar\u00eda Gil carcedo Garc\u00eda (vocal)<\/li>\n<li>sofia Ramos gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lucia Baraga\u00f1o Rio Se estudian 24 pacientes con adenocarcinoma nasosinusal mediante hibridaci\u00f3n gen\u00f3mica comparativa (hgc). La hgc [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,35,9,9224,1027,8846,156],"tags":[25235,25236,154859,6733,85240,25281],"class_list":["post-71008","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-ciencias-de-la-vida","category-ciencias-medicas","category-citogenetica","category-oncologia","category-oviedo","category-patologia","tag-carlos-suarez-nieto","tag-llorente-pendas-jose-luis","tag-lucia-baragano-rio","tag-luis-maria-gil-carcedo-garcia","tag-miquel-quer-agusti","tag-sofia-ramos-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71008","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71008"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71008\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71008"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71008"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71008"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}