{"id":71014,"date":"2018-03-09T23:15:32","date_gmt":"2018-03-09T23:15:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/enfermedad-autoinmune-del-oa%c2%addo-interno-resultados-de-una-estrategia-diagnostica-y-terapeutica\/"},"modified":"2018-03-09T23:15:32","modified_gmt":"2018-03-09T23:15:32","slug":"enfermedad-autoinmune-del-oa%c2%addo-interno-resultados-de-una-estrategia-diagnostica-y-terapeutica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/enfermedad-autoinmune-del-oa%c2%addo-interno-resultados-de-una-estrategia-diagnostica-y-terapeutica\/","title":{"rendered":"Enfermedad autoinmune del o\u00eddo interno: resultados de una estrategia diagn\u00f3stica y terap\u00e9utica."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garc\u00eda Callejo  Francisco Javier <\/strong><\/h2>\n<p>Por enfermedad autoinmune del o\u00eddo interno (eaoi) se entiende un desorden laber\u00edntico con caracter\u00edsticas cl\u00ednicas y epidemiol\u00f3gicas con entidad propia: individuos en la edad media de la vida, mayormente mujeres, que cursan con hipoacusia neurosensorial r\u00e1pidamente progresiva, unilateral o bilateral asim\u00e9trica, con potencial asociaci\u00f3n de signos o s\u00edntomas reumatol\u00f3gicos, alteraci\u00f3n en las pruebas de laboratorio sugestivas de inflamaci\u00f3n y una adecuada respuesta funcional a terapias inmunomoduladoras. Se trata por tanto de episodios de sordera fluctuantes e incluso reversibles con tratamiento m\u00e9dico, los corticoides sobre todo. Sin embargo, la rentabilidad diagn\u00f3stica de esta entidad mediante pruebas accesibles de imagen o histopatolog\u00eda a\u00fan resulta limitada.  hemos estudiado este rendimiento en tres bater\u00edas anal\u00edticas diferentes en 1068 individuos con cl\u00ednica sugestiva de eaoi (sujetos diagnosticados de sordera brusca, enfermedad de meniere, hipoacusia neurosensorial r\u00e1pidamente progresiva e hipoacusia neurosensorial en sujetos con enfermedades autoinmunes documentadas). Una bater\u00eda inicial de diecis\u00e9is marcadores inespec\u00edficos de inflamaci\u00f3n (que inclu\u00edan vsg, t\u00edtulos de igm, igg, iga, aslo, pcr, fibrin\u00f3geno, niveles de c3, c4, actividad ch50, fracciones igm, igg e iga del factor reumatoide, leucocitos, linfocitosis absoluta y cociente t4\/t8) evidenci\u00f3 una sensibilidad predictiva de respuesta a un tratamiento con deflazacort durante 60 d\u00edas del 75% cuando esta bater\u00eda mostraba tres o m\u00e1s par\u00e1metros alterados, y una especificidad del 88%. Estos indicadores fueron del 36 y 94% cuando se evalu\u00f3 una bater\u00eda de autoanticuerpos organoespec\u00edficos, y del 81 y 100% cuando se estudi\u00f3 la presencia de bandas de autoanticuerpos anticocleares mediante western-blot (wb).  la positividad en la prueba del wb permiti\u00f3 predecir en todos los casos respuesta adecuada a la corticoterapia. Adem\u00e1s, en un volumen de 8122<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Enfermedad autoinmune del o\u00eddo interno: resultados de una estrategia diagn\u00f3stica y terap\u00e9utica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Enfermedad autoinmune del o\u00eddo interno: resultados de una estrategia diagn\u00f3stica y terap\u00e9utica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garc\u00eda Callejo  Francisco Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/10\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jaime Marco Algarra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: daniel L\u00f3pez aguado <\/li>\n<li>Rafael Ram\u00edrez camacho (vocal)<\/li>\n<li>Miguel Armengot carceller (vocal)<\/li>\n<li>ausente Ausente (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garc\u00eda Callejo Francisco Javier Por enfermedad autoinmune del o\u00eddo interno (eaoi) se entiende un desorden laber\u00edntico con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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