{"id":71043,"date":"2004-02-11T00:00:00","date_gmt":"2004-02-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/neuropatologa%c2%ada-en-ratones-transgenicos-bo-prp-infectados-con-eeb\/"},"modified":"2004-02-11T00:00:00","modified_gmt":"2004-02-11T00:00:00","slug":"neuropatologa%c2%ada-en-ratones-transgenicos-bo-prp-infectados-con-eeb","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-agrarias\/neuropatologa%c2%ada-en-ratones-transgenicos-bo-prp-infectados-con-eeb\/","title":{"rendered":"Neuropatolog\u00eda en ratones transg\u00e9nicos (bo-prp) infectados con eeb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gutierrez Godinez Jessica Nineth <\/strong><\/h2>\n<p>El presente estudio ha sido planteado para contribuir al conocimiento de la patogenia de la eeb y del cuadro lesional que se origina en el enc\u00e9falo, utilizando ratones transg\u00e9nicos tg bo-prp y para determinar la utilidad de estos animales como herramienta par el estudio de esta enfermedad.  en nuestro estudio, \u00fanicamente el 20% de los animales manifestaron la sintomatolog\u00eda t\u00edpica de la eeb a partir de los 302 +- 26 dpi, corroborando la reducci\u00f3n en el per\u00edodo de incubaci\u00f3n. Adem\u00e1s, presentaron las lesiones estructurales caracter\u00edsticas (espongiosis astrocitosis y microgliosis) de la eeb.  durante nuestro estudio estructural y ultraestructural , la vacuolizaci\u00f3n neuronal y del neuropilo fue la lesi\u00f3n m\u00e1s frecuente en animales infectados a partir de los 180 dpi. La activaci\u00f3n de la microgl\u00eda y especialmente , la astrocitosis estuvieron presentes en nuestro estudio a partir del ac\u00famulo inicial de la prpres, present\u00e1ndose durante toda la experiencia y localiz\u00e1ndose , principalmente , alrededor de los dep\u00f3sitos de la prote\u00edna pri\u00f3n y de las \u00e1reas de vacuolizaci\u00f3n, lo que demuestra que se encuentra directamente relacionada con el ac\u00famulo de las prpres. Adem\u00e1s , hemos corroborado quela astrocitosis y la microgliosis participan en la producci\u00f3n y\/o fagocitosisi de la prote\u00edna pri\u00f3n al presentarse positividad frente al anticuerpo anti-prpres en sus citoplasmas.  hemos demostrado que la neurodegenaraci\u00f3n se encuentra asociada a las alteraciones del citoesqueleto neuronal por el establecimiento de los filamentos helicoidades pares (fhps)consitituidos principalmente por la prote\u00edna tau hiperforsoforilada demostrada al estudio inmunohistoqu\u00edmico. La prote\u00edna pri\u00f3n y la prote\u00edna tau hiperfosforilada se localizan en las mismas \u00e1reas, sugiriendo que se encuentran en asociaci\u00f3n aunque se desconozca su mecanismo. Estos resultados , corroboran la participaci\u00f3n de la prote\u00edna tau durante la patogenia de la eeb colo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Neuropatolog\u00eda en ratones transg\u00e9nicos (bo-prp) infectados con eeb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Neuropatolog\u00eda en ratones transg\u00e9nicos (bo-prp) infectados con eeb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gutierrez Godinez Jessica Nineth <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Carlos Gomez Villamandos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Sierra plana <\/li>\n<li>Juan  anselmo Perea remujo (vocal)<\/li>\n<li>rosario Moyano salvago (vocal)<\/li>\n<li>eduardo Ruiz villamor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gutierrez Godinez Jessica Nineth El presente estudio ha sido planteado para contribuir al conocimiento de la patogenia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,515,973,495],"tags":[40658,154930,40655,4491,19519,56326],"class_list":["post-71043","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-ciencias-veterinarias","category-cordoba","category-patologia-veterinaria","tag-eduardo-ruiz-villamor","tag-gutierrez-godinez-jessica-nineth","tag-jose-carlos-gomez-villamandos","tag-juan-anselmo-perea-remujo","tag-miguel-angel-sierra-plana","tag-rosario-moyano-salvago"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71043","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71043"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71043\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71043"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71043"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71043"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}