{"id":71061,"date":"2004-03-11T00:00:00","date_gmt":"2004-03-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/asociacion-del-complejo-mayor-de-histocompatibilidad-con-la-respuesta-al-tratamiento-con-infliximab-en-la-artritis-reumatoide\/"},"modified":"2004-03-11T00:00:00","modified_gmt":"2004-03-11T00:00:00","slug":"asociacion-del-complejo-mayor-de-histocompatibilidad-con-la-respuesta-al-tratamiento-con-infliximab-en-la-artritis-reumatoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/asociacion-del-complejo-mayor-de-histocompatibilidad-con-la-respuesta-al-tratamiento-con-infliximab-en-la-artritis-reumatoide\/","title":{"rendered":"Asociaci\u00f3n del complejo mayor de histocompatibilidad con la respuesta al tratamiento con infliximab en la artritis reumatoide"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marina Salido Olivares <\/strong><\/h2>\n<p>Objetivo: determinar si el polimorfismo del mhc se asocia con la respuesta al tratamiento con infliximab en la ar.  pacientesy m\u00e9todos:  se incluyeron 78 pacientes con ar refractaria al tratamiento previo con otros fames, que fueron tratados consecutivamente con infliximab del 2001 al 2002 en los servicios de reumatolog\u00edadel hospital cl\u00ednico san carlos y la paz de Madrid. Como grupo control se emplearon 342 individuos. Se recogieron variables cl\u00ednicas y anal\u00edticas previo a la terapia y a los 3 meses de iniciarla. Se consideraba paciente respondedor (pr), si exist\u00eda una mejor\u00eda igualo superior al 50 % del valor inicial del nao, nat y de dos \u00f3 m\u00e1s de estos  criterios: pcr, vsg, haq o vas. Se consideraba tambi\u00e9n pr si presentaba un 25 % de mejor\u00eda del valor inicial absoluto del das 28. Al a\u00f1o se valor\u00f3 el grado de respuesta mantenida. En el estudio bivariante de caracter\u00edsticas basales se utiliz\u00f3 la prueba?2 y la t de student, dependiendo de si la variable era cualitativa o cuantitativa respectivamente. En el estudio gen\u00e9tico se utiliz\u00f3 la ?2 y la odds ratio,y la pruebaexactade fisher en casos esperados menoresde 5.  resultados:  presentaban una media de 56,88 a\u00f1os (22-88 a\u00f1os), predominio de mujeres (76,9%), duraci\u00f3n media de la ar de 10 a\u00f1os y fr+ en un 84,62%. La mayor\u00eda tratadas con terapia combinada. Todos presentaban criterios de actividad al inicio. Tras la terapia se consideraron pr 41 ycomo pnr 37. Al a\u00f1o manten\u00edan la terapia56 pacientes (35 pr y21 pnr). Los haplotipos microsat\u00e9lites de tnf no presentaban diferencias, excepto tnf a11b4c1d3e3 (41% pr y 16% pnr). tampoco las presentaban los alelos del ep\u00edtopo compartido y los microsat\u00e9lites mica, 06s2223 y bat2. El \u00fanico alelo incrementado en pnr fue 06s273_3 (p=0,04, or=0,37). Este alelo se asocia al bat2_2 en poblaci\u00f3n control. En nuestro caso, esta asociaci\u00f3n se manten\u00eda en pnr (85%) pero no en pr (46%) con una p=0,02. En los pr se asociaban el<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Asociaci\u00f3n del complejo mayor de histocompatibilidad con la respuesta al tratamiento con infliximab en la artritis reumatoide<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Asociaci\u00f3n del complejo mayor de histocompatibilidad con la respuesta al tratamiento con infliximab en la artritis reumatoide <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marina Salido Olivares <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Benjamin Fernandez Gutierrez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Solana lara <\/li>\n<li>veronica Perez guijo (vocal)<\/li>\n<li>Jos\u00e9 Gonzalez dominguez (vocal)<\/li>\n<li>eliseo Pascual g\u00f3mez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marina Salido Olivares Objetivo: determinar si el polimorfismo del mhc se asocia con la respuesta al tratamiento [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[212,35,9,973,2445,957,2820,1737,139,877],"tags":[23197,1205,74639,154960,3760,101261],"class_list":["post-71061","post","type-post","status-publish","format-standard","hentry","category-biologia-humana","category-ciencias-de-la-vida","category-ciencias-medicas","category-cordoba","category-evaluacion-de-farmacos","category-farmacologia","category-genetica-humana","category-inmunologia","category-medicina-interna","category-reumatologia","tag-benjamin-fernandez-gutierrez","tag-eliseo-pascual-gomez","tag-jose-gonzalez-dominguez","tag-marina-salido-olivares","tag-rafael-solana-lara","tag-veronica-perez-guijo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71061"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71061\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}