{"id":71068,"date":"2004-04-11T00:00:00","date_gmt":"2004-04-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-de-transcripcion-implicados-en-el-desgaste-muscular-asociado-a-la-caquexia\/"},"modified":"2004-04-11T00:00:00","modified_gmt":"2004-04-11T00:00:00","slug":"factores-de-transcripcion-implicados-en-el-desgaste-muscular-asociado-a-la-caquexia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/factores-de-transcripcion-implicados-en-el-desgaste-muscular-asociado-a-la-caquexia\/","title":{"rendered":"Factores de transcripci\u00f3n implicados en el desgaste muscular asociado a la caquexia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rodrigo Ernesto Moore Carrasco <\/strong><\/h2>\n<p>La caquexia es un s\u00edndrome frecuentemente asociado al crecimiento tumoral, as\u00ed  como tambi\u00e9n a otros estados patol\u00f3gicos como son sepsis, sida (s\u00edndrome de  inmunodeficiencia adquirida), diabetes, etc. La caquexia se caracteriza por una  importante y progresiva p\u00e9rdida de peso corporal debida principalmente a la  desaparici\u00f3n de las reservas de grasa y a la disminuci\u00f3n de masa muscular. Est\u00e1  acompa\u00f1ada tambi\u00e9n de anorexia, n\u00e1useas, astenia, debilidad, alteraci\u00f3n de la  homeostasis hormonal e inmunodepresi\u00f3n.  sobre los factores de transcripci\u00f3n que podr\u00edan estar involucrados en el proceso de desgaste muscular observado en la caquexia (in vivo), se sabe muy poco, pero aparecen algunos factores como posibles candidatos tanto en el desencadenamiento como en la regulaci\u00f3n de este proceso. Nf-ks y ap-1 son dos factores de transcripci\u00f3n que est\u00e1n activados en distintos tejidos en procesos inflamatorios. Se ha descrito que nfksy ap-1 tienen una regulaci\u00f3n diferencial en m\u00fasculo esquel\u00e9tico de rata durante el proceso de sepsis. El mismo grupo ha determinado que c\/esp, otro factor de transcripci\u00f3n involucrado en el proceso de inflamaci\u00f3n, aumenta su actividad de uni\u00f3n al dna en m\u00fasculo de ratas s\u00e9pticas, y que este proceso es dependiente de glucocorticoides.  los objetivos de este estudio son: 1) analizar la regulaci\u00f3n de algunos factores de ranscripci\u00f3n en el m\u00fasculo esquel\u00e9tico durante la caquexia inducida por el crecimiento tumoral. 2) revertir el desgaste muscular asociado al crecimiento tumoral mediante estrategias basadas en factores de transcripci\u00f3n desde un punto de vista farmacol\u00f3gico. 3) aproximaciones a una terapia contra la caquexia mediante un adenovirus para la transferencia g\u00e9nica de un dominante negativo de ap-1.  los resultados obtenidos nos permiten concluir que el factor de transcripci\u00f3n ap-1 presenta una regulaci\u00f3n diferencial en el m\u00fasculo esquel\u00e9tico durante el crecimiento tumora<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores de transcripci\u00f3n implicados en el desgaste muscular asociado a la caquexia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores de transcripci\u00f3n implicados en el desgaste muscular asociado a la caquexia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rodrigo Ernesto Moore Carrasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josep M\u00aa Argil\u00e9s Huguet<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: silvia Busquets rius <\/li>\n<li>Antonio Felipe campo (vocal)<\/li>\n<li>angels Remessar jim\u00e9nez (vocal)<\/li>\n<li>Ana belen Alvarez palomo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodrigo Ernesto Moore Carrasco La caquexia es un s\u00edndrome frecuentemente asociado al crecimiento tumoral, as\u00ed como tambi\u00e9n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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