{"id":71099,"date":"2004-05-11T00:00:00","date_gmt":"2004-05-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/significacion-cla%c2%adnica-de-las-concentraciones-citosolicas-de-catepsina-d-en-el-cancer-de-mama\/"},"modified":"2004-05-11T00:00:00","modified_gmt":"2004-05-11T00:00:00","slug":"significacion-cla%c2%adnica-de-las-concentraciones-citosolicas-de-catepsina-d-en-el-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/significacion-cla%c2%adnica-de-las-concentraciones-citosolicas-de-catepsina-d-en-el-cancer-de-mama\/","title":{"rendered":"Significaci\u00f3n cl\u00ednica de las concentraciones citos\u00f3licas de catepsina d en el c\u00e1ncer de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Carlos Rodriguez  Diaz <\/strong><\/h2>\n<p>Justificaci\u00f3n y objetivos  la catepsina d es una prote\u00edna proteol\u00edtica que ha sido frecuentemente implicada como un factor pron\u00f3stico en el c\u00e1ncer primario de mama. En el presente estudio analizamos, mediante un m\u00e9todo de an\u00e1lisis inmuno radiom\u00e9trico, las concentraciones citos\u00f3licas intratumorales de la prote\u00edna en el c\u00e1ncer de mama primario, su relaci\u00f3n con los par\u00e1metros cl\u00ednicos y patol\u00f3gicos de los tumores y su significaci\u00f3n pron\u00f3stica en una amplia serie de pacientes con c\u00e1ncer de mama.  m\u00e9todos  en el estudio se incluyeron 1033 pacientes diagn\u00f3sticadas de carcinoma invasivo de mama. La catepsina d fue determinada en citosol de las muestras mediante un m\u00e9todo inmunoradiom\u00e9trico que determinaba las diferentes formas de catepsina (52k, 48k y 34k). La evaluaci\u00f3n del tiempo libre de enfermedad y de supervivencia total fue realizada en un grupo de 1003 pacientes sin evidencia de met\u00e1stasis en el momento del diagn\u00f3stico inicial. La media del periodo de seguimiento fue de 54 meses.  resultados  los niveles de catepsina d en los tumores mostraron una amplia variabilidad (n=1033; mediana 41; intervalo 0,9-2504; pmol\/mg de prote\u00edna). Adem\u00e1s, los niveles de captesina d fueron significativamente m\u00e1s elevados en los tumores de mama que en tejido no neopl\u00e1sico adyacente (n=10,10,4 (4,2-38,5) pmol\/mg de prote\u00edna; p=0,00009). El an\u00e1lisis estad\u00edstico tambi\u00e9n demostr\u00f3 que los niveles de catepsina d fueron significativamente m\u00e1s elevados en los tumores de mayor tama\u00f1o (t2-t4) que en aquellos de menor tama\u00f1o (t1) (p=0,017), en aquellos con afectaci\u00f3n ganglionar en comparaci\u00f3n con los tumores sin afectaci\u00f3n ganglionar (p=0,004). Los niveles de catepsina d fueron tambi\u00e9n significativamente m\u00e1s elevados en los tumores de tipo histol\u00f3gico ductal que en los tumores de otros tipos histol\u00f3gicos (p=0,001), as\u00ed como en los que presentaban un menor grado de diferenciaci\u00f3n con respecto a los tumores bien diferenc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Significaci\u00f3n cl\u00ednica de las concentraciones citos\u00f3licas de catepsina d en el c\u00e1ncer de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Significaci\u00f3n cl\u00ednica de las concentraciones citos\u00f3licas de catepsina d en el c\u00e1ncer de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Carlos Rodriguez  Diaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Vizoso Pi\u00f1eiro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Schneider fontan <\/li>\n<li>Mar\u00eda  del mar Abad hernandez (vocal)<\/li>\n<li>\u00e1ngel Jim\u00e9nez lacave (vocal)<\/li>\n<li> Sirvent calvera Juan  Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Carlos Rodriguez Diaz Justificaci\u00f3n y objetivos la catepsina d es una prote\u00edna proteol\u00edtica que ha sido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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