{"id":71177,"date":"2004-11-11T00:00:00","date_gmt":"2004-11-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estres-oxidativo-y-electrofisiologia-ocular-efectos-del-ebselen\/"},"modified":"2004-11-11T00:00:00","modified_gmt":"2004-11-11T00:00:00","slug":"estres-oxidativo-y-electrofisiologia-ocular-efectos-del-ebselen","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estres-oxidativo-y-electrofisiologia-ocular-efectos-del-ebselen\/","title":{"rendered":"Estres oxidativo y electrofisiolog\u00eda ocular: efectos del ebselen."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Belen Romero Gomez <\/strong><\/h2>\n<p>En el presente trabajo de investigaci\u00f3n hemos estudiado tres procesos que implican neurodegeneraci\u00f3n: enfermedad de alzheimer, diabetes y alcoholismo cr\u00f3nico correlacionando, tras desarrollar modelos experimentales con afectaci\u00f3n del sistema retininano, datos funcionales in vivo, mediante electrorretinograf\u00eda, con marcadores bioqu\u00edmicos de estr\u00e9s oxidativo (mda y gsh). Y c\u00f3mo la administraci\u00f3n de un antioxidante selenorg\u00e1nico: el ebselen, interacciona en la fisiopatolog\u00eda de estos procesos.  material y m\u00e9todos: se inyectaron intrav\u00edtreo 3 microlitros (2 nmoles) de p\u00e9ptido beta-amiloide 1-40 envejecido y 25-35 fresco y envejecido para el modelo de demencia tipo alzheimer. Se indujo la diabetes por inyecci\u00f3n \u00fanica de aloxana 200mg\/sc. Y para el modelo de alcoholismo cr\u00f3nico se administr\u00f3 dieta l\u00edquida alc\u00f3holica (lieber di carli) durante 6 semanas, con suplementos de ebselen en la dieta en estos dos \u00faltimos modelos. Tras la realizaci\u00f3n de electrorretinogramas seriados, se determin\u00f3 mda y gsh en homogenado de ojos sin cristalino.  resultados: en el primer modelo el valor de mda a las 96h (0.692 nmol\/mg<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estres oxidativo y electrofisiolog\u00eda ocular: efectos del ebselen.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estres oxidativo y electrofisiolog\u00eda ocular: efectos del ebselen. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Belen Romero Gomez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Romero Gomez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: salvador Lluch lopez <\/li>\n<li>Mar\u00eda Miranda sanz (vocal)<\/li>\n<li>Manuel D\u00edaz llopis (vocal)<\/li>\n<li>concepcion Vilela soler (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Belen Romero Gomez En el presente trabajo de investigaci\u00f3n hemos estudiado tres procesos que implican neurodegeneraci\u00f3n: enfermedad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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