{"id":71236,"date":"2018-03-09T23:15:50","date_gmt":"2018-03-09T23:15:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sindrome-de-moebius-estudio-de-sus-mecanismos-embriogeneticos\/"},"modified":"2018-03-09T23:15:50","modified_gmt":"2018-03-09T23:15:50","slug":"sindrome-de-moebius-estudio-de-sus-mecanismos-embriogeneticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sindrome-de-moebius-estudio-de-sus-mecanismos-embriogeneticos\/","title":{"rendered":"Sindrome de moebius: estudio de sus mecanismos embriogeneticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Perez Aytes <\/strong><\/h2>\n<p>Introduccion .-  el s\u00edndrome de moebius debe su nombre al neur\u00f3logo alem\u00e1n paul julius moebius el cual, entre 1888-1892, comunic\u00f3 una serie de pacientes que presentaban par\u00e1lisis cong\u00e9nita, bilateral, de nervios craneales vii y vi (facial y motor ocular externo) adem\u00e1s de otras malformaciones asociadas. Aunque parece que el origen del sindrome estar\u00eda en una destruccion (degeneracion secundaria) \u00f3 una agenesia (degeneracion primaria) de los nucleos de los nervios craneales, la etiolog\u00eda y patogenia del mismo siguen siendo objeto de debate. En 1986 se propuso que el mecanismo patog\u00e9nico b\u00e1sico en el sindrome de moebius ser\u00eda una insuficiencia en el flujo sangu\u00edneo en el territorio de la arteria basilar \u00f3 sus precedentes embrionarias, arterias a partir de las cuales se origina el flujo vascular a la zona de los nucleos de los nervios craneales. Esta hip\u00f3tesis tambien explicar\u00eda las anomal\u00edas m\u00fasculo-esquel\u00e9ticas que con frecuencia se asocian al moebius ya que la isquemia podr\u00eda afectar al mismo tiempo a las arterias tor\u00e1cica interna, subclavia y vertebral.  planteamiento de problema.-  justificaci\u00f3n:  existe confusion en la delimitacion del fenotipo y la informacion sobre el sindrome esta dispersa por publicaciones de diferentes especialidades y el conocimiento de su historia natural ha estado basado hasta ahora en casos aislados o experiencias de un hospital concreto.  objetivos: obtener datos sobre frecuencia del s. Moebius en poblaci\u00f3n espa\u00f1ola. mediante estudio clinico\/genealogico obtener datos para asesoramiento genetico. buscar factores de riesgo que nos indiquen si hay bases s\u00f3lidas para la hip\u00f3tesis vascular y por otra parte que nos permitan adoptar medidas preventivas. obtener informacion para un mejor conocimiento de la historia natural. delinear y delimitar mejor el fenotipo clinico. Sentar bases para posteriores estudios de genetica molecular. Con la experiencia acumulada, establecer en Valencia un<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sindrome de moebius: estudio de sus mecanismos embriogeneticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sindrome de moebius: estudio de sus mecanismos embriogeneticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Perez Aytes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Mart\u00ednez Soriano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco jos\u00e9 S\u00e1nchez del campo <\/li>\n<li>virginio Garc\u00eda mart\u00ednez (vocal)<\/li>\n<li>Manuel Herrera lara (vocal)<\/li>\n<li>ignacio Santiago Alvarez Miguel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Perez Aytes Introduccion .- el s\u00edndrome de moebius debe su nombre al neur\u00f3logo alem\u00e1n paul julius [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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