{"id":71241,"date":"2018-03-09T23:15:50","date_gmt":"2018-03-09T23:15:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/vias-intracelulares-implicadas-en-la-reduccion-del-numero-de-celulas-lactotrofas-en-la-diabetes-mellitus-experimental\/"},"modified":"2018-03-09T23:15:50","modified_gmt":"2018-03-09T23:15:50","slug":"vias-intracelulares-implicadas-en-la-reduccion-del-numero-de-celulas-lactotrofas-en-la-diabetes-mellitus-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/vias-intracelulares-implicadas-en-la-reduccion-del-numero-de-celulas-lactotrofas-en-la-diabetes-mellitus-experimental\/","title":{"rendered":"Vias intracelulares implicadas en la reduccion del numero de celulas lactotrofas en la diabetes mellitus experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Arroba Espinosa Ana Isabel <\/strong><\/h2>\n<p>Durante la diabetes mellitus se producen cambios en al secrecci\u00f3n hormonal que pueden afectar al correcto funcionamiento del organismo. En nuestro trabajo hemos utilizado ratas de laboratorio a las que se les ha inducido dm mediante inyecci\u00f3n de estreptozotocina. Se ha detectado una disminuci\u00f3n en el n\u00famero de lactotrofas durante la dm experimental, vi\u00e9ndose que esta muerte es por apoptosis. Las v\u00edas de se\u00f1alizaci\u00f3n apopt\u00f3ticas estudiadas: v\u00eda extr\u00ednseca y v\u00eda intr\u00ednseca, se encuentran activadas en distintos grados en las hip\u00f3fisis de las ratas controles y diab\u00e9ticas. Se deduce que las lactotrofas pueden estar muriendo por la activaci\u00f3n de la caspasa-8, ejecutora de la v\u00eda intr\u00ednseca; mientras que en el recambio normal que se produce en la hip\u00f3fisis control  viene mediado por la acci\u00f3n de las distintas caspasas que participan en la v\u00eda intrinseca.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Vias intracelulares implicadas en la reduccion del numero de celulas lactotrofas en la diabetes mellitus experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Vias intracelulares implicadas en la reduccion del numero de celulas lactotrofas en la diabetes mellitus experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Arroba Espinosa Ana Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Argente Oliver<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Quero jim\u00e9nez <\/li>\n<li>Manuel Hern\u00e1ndez rodr\u00edguez (vocal)<\/li>\n<li> Frago fernandez laura Mar\u00eda (vocal)<\/li>\n<li>Luis Miguel Garc\u00eda segura (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arroba Espinosa Ana Isabel Durante la diabetes mellitus se producen cambios en al secrecci\u00f3n hormonal que pueden [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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