{"id":71256,"date":"2018-03-09T23:15:50","date_gmt":"2018-03-09T23:15:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-protea%c2%adna-tau-fosforilacion-y-ensamblaje\/"},"modified":"2018-03-09T23:15:50","modified_gmt":"2018-03-09T23:15:50","slug":"la-protea%c2%adna-tau-fosforilacion-y-ensamblaje","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/la-protea%c2%adna-tau-fosforilacion-y-ensamblaje\/","title":{"rendered":"La prote\u00edna tau: fosforilaci\u00f3n y ensamblaje."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto G\u00f3mez Ramos <\/strong><\/h2>\n<p>Tau es una prote\u00edna asociada a microt\u00fabulos que en condiciones normales cumple funciones de estabilizaci\u00f3n de los mismos. En condiciones patol\u00f3gicas se autoagrega en forma hiperfosforilada formando estructuras filamentosas en las enfermedades llamadas tauopat\u00edas. En este trabajo se ha abordado el tema de la fosforilaci\u00f3n y ensamblaje aberrantes de la prote\u00edna tau en cuanto a su relaci\u00f3n con los productos del estr\u00e9s oxidativo 4-hne y acrole\u00edna, descubriendo que la acrole\u00edna induce un aumento en la fosforilaci\u00f3n de tau que se debe fundamentalmente a la acci\u00f3n de la quinasa activada por estr\u00e9s p38, el 4-hne act\u00faa sobre la prote\u00edna tau fosforilada induciendo la formaci\u00f3n de polimeros similares en cuanto a estructura a los filamentos encontrados en la tauopat\u00eda demencia supranuclear progresiva (psp). Por otro lado se ha realizado un sistema celular basado en las c\u00e9lulas de insecto sf9 y su vector infectivo natural, los baculovirus para la formaci\u00f3n de filamentos de tau. Se ha demostrado que la presencia de tres de las mutaciones de tau encontradas en la tauopat\u00eda ftdp-17 (g272v, p301l y r406w), son suficientes para la formaci\u00f3n de filamentos de tau similares a los encontrados en las tauopat\u00edas, que con estas tres mutaciones tau se hiperfosforila m\u00e1s que el tau silvestre y que esta fosforilaci\u00f3n es debida fundamentalmente a la acci\u00f3n de la quinasa gsk3. La inhibici\u00f3n selectiva de esta quinasa con litio es suficiente para evitar de forma significativa la formaci\u00f3n de estos filamentos. Por \u00faltimo, hemos abordado el tema de la regulaci\u00f3n de la quinasa gsk3, descubriendo que el producto tungstato s\u00f3dico, inhibe la fosforilaci\u00f3n de tau en aquellos sitios que requieren una fosforilaci\u00f3n previa ( \u00abprimados\u00bb), los cuales tienen una mayor relevancia en cuanto a la interacci\u00f3n de tau con los microt\u00fabulos ya que la fosforilaci\u00f3n en estos sitios inhibe mas la interacci\u00f3n entre tau y tubulina que la fosforilaci\u00f3n en sitio<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La prote\u00edna tau: fosforilaci\u00f3n y ensamblaje.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La prote\u00edna tau: fosforilaci\u00f3n y ensamblaje. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto G\u00f3mez Ramos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Avila De Grado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Moreno <\/li>\n<li>pilar G\u00f3mez ramos (vocal)<\/li>\n<li>Juan  Carlos Zabala (vocal)<\/li>\n<li>Antonio Pascual (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto G\u00f3mez Ramos Tau es una prote\u00edna asociada a microt\u00fabulos que en condiciones normales cumple funciones de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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