{"id":71343,"date":"2018-03-09T23:15:59","date_gmt":"2018-03-09T23:15:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-marcadores-de-macrofagos-relacionados-con-aterosclerosis-presencia-de-xantomas-en-hipercolesterolemia-familiar-y-respuesta-a-atorvastatina\/"},"modified":"2018-03-09T23:15:59","modified_gmt":"2018-03-09T23:15:59","slug":"estudio-de-marcadores-de-macrofagos-relacionados-con-aterosclerosis-presencia-de-xantomas-en-hipercolesterolemia-familiar-y-respuesta-a-atorvastatina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/estudio-de-marcadores-de-macrofagos-relacionados-con-aterosclerosis-presencia-de-xantomas-en-hipercolesterolemia-familiar-y-respuesta-a-atorvastatina\/","title":{"rendered":"Estudio de marcadores de macr\u00f3fagos relacionados con aterosclerosis, presencia de xantomas en hipercolesterolemia familiar y respuesta a atorvastatina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Artieda Ose\u00f1alde <\/strong><\/h2>\n<p>Los macr\u00f3fagos tienen funciones esenciales en todas las fases de la aterosclerosis, desde el desarrollo de la estr\u00eda grasa al proceso que contribuye a la ruptura de la placa y al evento cardiovascular. Por ello, la identificaci\u00f3n de marcadores de macr\u00f3fagos activados posee un enorme inter\u00e9s, ya que puede ser una herramienta muy \u00fatil para predecir el riesgo cardiovascular individual. la enzima quitotriosidasa, por ser un marcador de macr\u00f3fagos activados, podr\u00eda ser utilizada como un marcador de aterosclerosis \u00abin vivo\u00bb. En este trabajo se describi\u00f3 que la actividad s\u00e9rica de la enzima quitotriosidasa se encontraba significativamente elevada en sujetos con patolog\u00eda aterosclerosa,153 sujetos con ictus aterotromb\u00f3tico y 133 sujetos con enfermedad isqu\u00e9mica coronaria, respecto a 148 sujetos control. Adem\u00e1s, la actividad s\u00e9rica quitotriosidasa aumentaba con el grado de estenosis carot\u00eddea en sujetos que hab\u00edan presentado un ictus aterotromb\u00f3tico. Por otra parte, la concentraci\u00f3n de la prote\u00edna c reactiva en suero se encontraba significativamente elevada en sujetos con patolog\u00eda aterosclerosa respecto a controles. Sin embargo, no exist\u00eda correlaci\u00f3n entre la actividad s\u00e9rica quitotriosidasa y la concentraci\u00f3n de la prote\u00edna c reactiva en ninguno de los grupos del estudio, lo que indica que ambos marcadores son mamadores inflamatorios independientes. Adem\u00e1s, se llev\u00f3 a cabo un estudio prospectivo de una media de 4 a\u00f1os con el grupo de sujetos con enfermedad isqu\u00e9mica coronaria, para analizar el valor predictivo de la actividad s\u00e9rica quitotriosidasa en la predicci\u00f3n de eventos cardiovasculares, y comparado con el de la prote\u00edna c reactiva. Los resultados del an\u00e1lisis indicaron que la actividad s\u00e9rica quitotriosidasa basal predec\u00eda el riesgo de eventos cardiovasculares en sujetos con enfermedad coronaria estable en los siguientes 4 a\u00f1os con un valor predictivo similar al de la prote\u00edna c reactiva, siendo mejor marcador de aquellos e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de marcadores de macr\u00f3fagos relacionados con aterosclerosis, presencia de xantomas en hipercolesterolemia familiar y respuesta a atorvastatina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de marcadores de macr\u00f3fagos relacionados con aterosclerosis, presencia de xantomas en hipercolesterolemia familiar y respuesta a atorvastatina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Artieda Ose\u00f1alde <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Civeira Murillo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Ordov\u00e1s mu\u00f1oz Jos\u00e9 Mar\u00eda <\/li>\n<li>Jos\u00e9 Antonio Paramo fernandez (vocal)<\/li>\n<li>Antonio Mart\u00ednez mart\u00ednez (vocal)<\/li>\n<li>pilar Lasierra d\u00edaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Artieda Ose\u00f1alde Los macr\u00f3fagos tienen funciones esenciales en todas las fases de la aterosclerosis, desde el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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