{"id":71369,"date":"2018-03-09T23:15:59","date_gmt":"2018-03-09T23:15:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucion-a-la-farmacodinamia-del-clorhidrato-de-doxepina-en-preparaciones-de-musculo-liso\/"},"modified":"2018-03-09T23:15:59","modified_gmt":"2018-03-09T23:15:59","slug":"contribucion-a-la-farmacodinamia-del-clorhidrato-de-doxepina-en-preparaciones-de-musculo-liso","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/contribucion-a-la-farmacodinamia-del-clorhidrato-de-doxepina-en-preparaciones-de-musculo-liso\/","title":{"rendered":"Contribuci\u00f3n a la farmacodinamia del clorhidrato de doxepina en preparaciones de m\u00fasculo liso"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Pascual Samaniego <\/strong><\/h2>\n<p>El clorhidrato de doxepina es un f\u00e1rmaco antidepresivo tric\u00edclico cl\u00e1sico. en el presente trabajo se estudia su efecto sobre preparaciones de \u00f3rgano aislado (conducto deferente y \u00fatero de rata e ileon aislado de cobaya).  material y m\u00e9todos.- Se utilizaron preparaciones de conducto deferente aislado de rata para el estudio de las interacciones de la doxepina con noradrenalina, dopamina y cloruro de postasio; \u00fatero aislado de rata para el estudio de las interaciones con histamina, ya para el estudio de las interacciones de la doxepina con acetilcolina, histamina y cloruro de potasio. se calcularon los valores de pa2 y de pd2.  resultados y discusi\u00f3n.- El clorhidrato de doxepina se comporta como antagonista no competitigvo de dopamina en la preparaci\u00f3n de conducto deferente aislado de rata. Tambi\u00e9n inhibe la contracci\u00f3n inducida por el potasio en la misma preparaci\u00f3n. El clorhidrato de doxepina se comporta como antagonista competitivo de acetilcolina e histamina en la preparaci\u00f3n de ileon aislado de cobaya e inhibe la contracci\u00f3n indicida por el potasio en la misma preparaci\u00f3n. el clorhidrato de doxepina se comporta como antagonista competitivo de la histamina en la preparaci\u00f3n de \u00fatero aislado de rata depolarizado con potasio y como antagonista no competitivo de serotonina y oxitocina en la misma preparaci\u00f3n. Tambi\u00e9n inhibe la contracci\u00f3n inducida por el potasio en la preparaci\u00f3n  de \u00fatero aislado de rata.  conclusi\u00f3n.- El clorhidrato de doxepina al igual que otros antidepresivos tric\u00edcliocos cl\u00e1sicos se comporta como estabilizador inespec\u00edfico de membrana, bloqueando los canales de sodico dependientes de voltaje, lo que puede explicar su cardiotoxicidad en sobredosis y su potencial utilidad en el tratamiento del dolor cr\u00f3nico neurop\u00e1tico. Tambi\u00e9n es importante destacar su notable poder antihistam\u00ednico h1 (pa2 = 9.22+ &#8211; 0.007).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribuci\u00f3n a la farmacodinamia del clorhidrato de doxepina en preparaciones de m\u00fasculo liso<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribuci\u00f3n a la farmacodinamia del clorhidrato de doxepina en preparaciones de m\u00fasculo liso <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Pascual Samaniego <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ernesto Fernandez  Del Busto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Fern\u00e1ndez de la gandara <\/li>\n<li>Francisco Zaragoza garcia (vocal)<\/li>\n<li>angela Alsasua del valle (vocal)<\/li>\n<li> Serrano molina Jos\u00e9 s. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Pascual Samaniego El clorhidrato de doxepina es un f\u00e1rmaco antidepresivo tric\u00edclico cl\u00e1sico. en el presente trabajo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,12692,189,483,7464,324,12451],"tags":[6042,25396,12638,4080,155544,54041],"class_list":["post-71369","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-efecto-de-las-drogas","category-farmacodinamia","category-mecanismos-de-accion-de-los-farmacos","category-psicofarmacologia","category-psicologia","category-valladolid","tag-angela-alsasua-del-valle","tag-ernesto-fernandez-del-busto","tag-fernando-fernandez-de-la-gandara","tag-francisco-zaragoza-garcia","tag-miguel-pascual-samaniego","tag-serrano-molina-jose-s"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71369","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71369"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71369\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71369"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71369"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}