{"id":71399,"date":"2018-03-09T23:16:03","date_gmt":"2018-03-09T23:16:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-papel-de-las-gtpasas-rho-y-rac-en-la-activacion-y-senalizacion-de-la-integrina-lfa-1-en-linfocitos-t\/"},"modified":"2018-03-09T23:16:03","modified_gmt":"2018-03-09T23:16:03","slug":"caracterizacion-del-papel-de-las-gtpasas-rho-y-rac-en-la-activacion-y-senalizacion-de-la-integrina-lfa-1-en-linfocitos-t","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-del-papel-de-las-gtpasas-rho-y-rac-en-la-activacion-y-senalizacion-de-la-integrina-lfa-1-en-linfocitos-t\/","title":{"rendered":"Caracterizaci\u00f3n del papel de las gtpasas rho y rac en la activaci\u00f3n y se\u00f1alizaci\u00f3n de la integrina lfa-1 en linfocitos t"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lorena S\u00e1nchez Mart\u00edn <\/strong><\/h2>\n<p>La integrina lfa-1 (alfalbeta2, cd11a\/cd18) es una mol\u00e9cula clave en la migraci\u00f3n linfocitaria y en la presentaci\u00f3n antig\u00e9nica. Estos procesos llevan asociados adem\u00e1s una polarizaci\u00f3n de la morfolog\u00eda del linfocito inducida por se\u00f1ales mediadas por lfa-1. En este contexto, la reorganizaci\u00f3n del citoesqueleto celular desempe\u00f1a un papel regulador tanto de la actividad de lfa-1 como en los cambios morfol\u00f3gicos que media. As\u00ed las gtpasas rho y rac, debido al control que ejercen sobre la organizaci\u00f3n citoesquel\u00e9tica, son buenos candidatos reguladores de la actividad de lfa-1 y de las se\u00f1ales mediadas por esta integrina.  los resultados presentados en esta tesis demuestran que la inhibici\u00f3n de la gtpasa rho, de su efecto rock o de la gtpasa rac induce la despolimierizaci\u00f3n parcial de los filamentos de actina, permitiendo la activaci\u00f3n de lfa-1 por agregaci\u00f3n en la membrana sin inducirse incrementos en la afinidad por su ligando. Adem\u00e1s la inhibici\u00f3n de rho y rock, induce un incremento en la adhesi\u00f3n a icam-1 y los cambios en la morfolog\u00eda mediados por lfa-1. la inhibici\u00f3n de rho, rock o rac induce la activaci\u00f3n de la tirosina quinasa pyk2 mediada por la interacci\u00f3n de lfa-1 activa con su icam-1 y no de forma directa. Estos estudios aportan adem\u00e1s datos sobre la se\u00f1alizaci\u00f3n de lfa-1 hacia el citoesqueleto. As\u00ed lfa-1 induce la activaci\u00f3n transitoria de la gtpasa rac, necesaria para la inducci\u00f3n de cambios morfol\u00f3gicos. En esta se\u00f1alizaci\u00f3n hacia rac, lfa-1 modula la actividad de rac a trav\u00e9s de dos v\u00edas diferenciadas; una induce la activaci\u00f3n de rac a trav\u00e9s de la fosforilaci\u00f3n y activaci\u00f3n del gef vav, mientras que la activaci\u00f3n m\u00e1s tard\u00eda del eje pi3k\/akt inducida tambi\u00e9n por lfa-1, inactiva a rac.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n del papel de las gtpasas rho y rac en la activaci\u00f3n y se\u00f1alizaci\u00f3n de la integrina lfa-1 en linfocitos t<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n del papel de las gtpasas rho y rac en la activaci\u00f3n y se\u00f1alizaci\u00f3n de la integrina lfa-1 en linfocitos t <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lorena S\u00e1nchez Mart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Caba\u00f1as Guti\u00e9rrez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin gregorio Zapata gonzalez <\/li>\n<li>joaqu\u00edn Teixid\u00f3 calvo (vocal)<\/li>\n<li>Francisco Sanchez Madrid (vocal)<\/li>\n<li> Garc\u00eda pardo m. de los \u00e1ngeles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lorena S\u00e1nchez Mart\u00edn La integrina lfa-1 (alfalbeta2, cd11a\/cd18) es una mol\u00e9cula clave en la migraci\u00f3n linfocitaria y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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