{"id":71415,"date":"2018-03-09T23:16:03","date_gmt":"2018-03-09T23:16:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-los-endocanabinoides-sobre-la-regulacion-del-factor-de-transcripcion-nf-kb-implicaciones-terapeuticas-en-inflamacion-y-sida\/"},"modified":"2018-03-09T23:16:03","modified_gmt":"2018-03-09T23:16:03","slug":"efecto-de-los-endocanabinoides-sobre-la-regulacion-del-factor-de-transcripcion-nf-kb-implicaciones-terapeuticas-en-inflamacion-y-sida","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efecto-de-los-endocanabinoides-sobre-la-regulacion-del-factor-de-transcripcion-nf-kb-implicaciones-terapeuticas-en-inflamacion-y-sida\/","title":{"rendered":"Efecto de los endocanabinoides sobre la regulaci\u00f3n del factor de transcripci\u00f3n nf-kb implicaciones terap\u00e9uticas en inflamaci\u00f3n y sida."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rocio Sancho Zapatero <\/strong><\/h2>\n<p>El sistema canabinoide est\u00e1 compuesto por mediadores lip\u00eddicos (endocanabinoides y endovanilloides),por enzimas que regulan su metabolismo, y por receptores que median sus acciones biol\u00f3gicas. Estos mediadores lip\u00eddicos ejercen sus m\u00faltiples acciones biol\u00f3gicas tanto por mecanismos dependientes como independientes de su uni\u00f3n a los receptores conocidos. La identificaci\u00f3n de los componentes de este sistema y su posibilidad de manipulaci\u00f3n farmacol\u00f3gica ha representando un importante avance en el campo de  la neuroinmunolog\u00eda.  la ocupaci\u00f3n del tcr en las c\u00e9lulas t por ant\u00edgeno da lugar a una cascada de activaci\u00f3n de se\u00f1ales de transmisi\u00f3n intracelulares que culminan con la regulaci\u00f3n de determinados factores de transcripci\u00f3n inducibles responsables de la reprogramaci\u00f3n g\u00e9nica. Dentro de estos factores de transcripci\u00f3n se encuentra el factor nuclear kappa b (nf-?B). Este factor de transcripci\u00f3n pertenece a la familia nf-kb\/rel, la cual engloba a una familia de factores de transcripci\u00f3n que desempe\u00f1an un papel muy importante en la regulaci\u00f3n de  genes relacionados con el crecimiento y desarrollo celular, en la respuesta inmune e inflamatoria y en la replicaci\u00f3n del vih-1. En este trabajo hemos demostrado que: 1)el endocannabinoideanandamida inhibe la ruta can\u00f3nica de activaci\u00f3n de nf-?B inducida por tnfa. Esta inhibici\u00f3n tiene lugar a nivel del complejo ikk y m\u00e1s en concreto actuando sobre la subunidad ikkb, siendo el efecto independiente de los receptores de cb y trpv1; 2)los endovanilloides n-araquidonoil-dopaminay n-oleil-dopamina inhiben la proliferaci\u00f3n de los  linfocitos t inducida por ant\u00edgeno mediante un mecanismo independiente de receptor y que implica un elemento com\u00fan en la ruta de activaci\u00f3n de nf-kb, nfat y ap-1; y 3) n-araquidonoil-dopaminainhibe la replicaci\u00f3n del vih-1 a nivel transcripcional mediante un mecanismoque implica la activaci\u00f3nde nf-?B yque es independientede los receptores<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de los endocanabinoides sobre la regulaci\u00f3n del factor de transcripci\u00f3n nf-kb implicaciones terap\u00e9uticas en inflamaci\u00f3n y sida.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de los endocanabinoides sobre la regulaci\u00f3n del factor de transcripci\u00f3n nf-kb implicaciones terap\u00e9uticas en inflamaci\u00f3n y sida. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rocio Sancho Zapatero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Mu\u00f1oz Blanco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Sanchez criado Jos\u00e9 eugenio <\/li>\n<li>Manuel Guzm\u00e1n pastor (vocal)<\/li>\n<li>Mar\u00eda  del mar Malagon poyato (vocal)<\/li>\n<li>carmen Guaza rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rocio Sancho Zapatero El sistema canabinoide est\u00e1 compuesto por mediadores lip\u00eddicos (endocanabinoides y endovanilloides),por enzimas que regulan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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