{"id":71508,"date":"2018-03-09T23:16:07","date_gmt":"2018-03-09T23:16:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-delecciones-en-el-carcinoma-pulmonar-no-microca%c2%adtico\/"},"modified":"2018-03-09T23:16:07","modified_gmt":"2018-03-09T23:16:07","slug":"estudio-de-delecciones-en-el-carcinoma-pulmonar-no-microca%c2%adtico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-delecciones-en-el-carcinoma-pulmonar-no-microca%c2%adtico\/","title":{"rendered":"Estudio de delecciones en el carcinoma pulmonar no microc\u00edtico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Saez Rodr\u00edguez <\/strong><\/h2>\n<p>El material de trabajo fueron tejidos incluidos en parafina obtenidos a partir de 30 piezas quir\u00fargicas de pulmones con carcinoma pulmonar no microc\u00edtico procedentes de enfermos del hospital cl\u00ednico de Madrid.  tambi\u00e9n se incluyeron 20 citolog\u00edas procedentes de cepillados bronquiales de pacientes sin evidencia de malignidad. Los criterios de selecci\u00f3n era la presencia de c\u00e9lulas bronquiales e inflamatorias y un seguimiento de estos pacientes de al menos cinco a\u00f1os sin evidencia de malignidad.  se realiz\u00f3 la microdisecci\u00f3n de poblaciones celulares de linfocitos y de c\u00e9lulas tumorales o peritumorales procedentes de tejidos incluidos en parafina y te\u00f1idas con hematoxilina-eosina. Tambi\u00e9n se realiz\u00f3 la microdisecci\u00f3n de las c\u00e9lulas bronquiales e inflamatorias procedentes de citolog\u00edas benignas fueron te\u00f1idas con la t\u00e9cnica de papanicolaou.  posteriormente se realiz\u00f3 la extracci\u00f3n del adn de las c\u00e9lulas microdiseccionadas y la posterior pcr (reacci\u00f3n en cadena de la polimerasa) de las regiones microsat\u00e9lites:5q21 (d5s346), 3p14.3 (d3s1300), 9p21 (d9s157) y 17p (tp53).  el an\u00e1lisis de la perdida de heterocigosidad (loh) se realiz\u00f3 en el secuenciador autom\u00e1tico abi-prism 310 genetic analyser de la casa comercial applied biosystemas con el software genescan 2.1.  los resultados obtenidos fueron los siguientes:  las c\u00e9lulas tumorales mostraron loh en un 72% de los casos informativos en 5q21 (apc).  47% en 3p21  48% en 9p21 (p16)  33% en 17p13 (p53)  de los 30 casos utilizados se encontraron delecciones al\u00e9licas en c\u00e9lulas tumorales en 24 (80%) de ellos: 9 afectaba \u00fanicamente a uno de los locus, 10 casos con delecciones en dos regiones cromos\u00f3micas, 4 casos con tres loci incluidos y uno con loh en todas las regiones cromos\u00f3micas analizadas.  en el an\u00e1lisis de la mucosa peritrumoral de las c\u00e9lulas bronauiales adyacentes al tumor se encontraron delecciones en un n\u00famero significativo de los casos:  37,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de delecciones en el carcinoma pulmonar no microc\u00edtico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de delecciones en el carcinoma pulmonar no microc\u00edtico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Saez Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julian Sanz Ortega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benjam\u00edn Fern\u00e1ndez ruiz <\/li>\n<li> Ortego saez de letama Javier (vocal)<\/li>\n<li>Mar\u00eda Villarubias jose (vocal)<\/li>\n<li>mario Martinez ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Saez Rodr\u00edguez El material de trabajo fueron tejidos incluidos en parafina obtenidos a partir de 30 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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